小剂量阿司匹林对有复发性流产史妊娠期妇女的临床疗效

Clinical Effect of Low Dose Aspirin on Pregnant Women with History of Recurrent Abortion

目的:研究有复发性流产史妊娠期妇女小剂量阿司匹林的临床疗效。方法:回顾性选取2018年1月-2020年1月本院有复发性流产史妊娠期妇女100例,依据治疗方法分为小剂量阿司匹林联合低分子肝素钠治疗组(联合治疗组,n=50)、单独低分子肝素钠治疗组(单独治疗组,n=50)两组,统计分析两组孕妇的激素水平、免疫功能、保胎成功情况、不良反应发生情况。结果:联合治疗组患者治疗后1个月较治疗前的血清E2、P、hCG水平升高幅度均显著高于单独治疗组(P<0.05)。联合治疗组患者治疗后1个月较治疗前的血清IL-4水平升高幅度,血清IFN-γ水平、IFN-γ/IL-4降低幅度均显著高于单独治疗组(P<0.05)。在保胎成功率方面,联合治疗组为88.0%(44/50),单独治疗组为56.0%(28/50),前者显著高于后者(P<0.05)。在不良反应发生率方面,联合治疗组为2.0%(1/50),单独治疗组为6.0%(3/50),两组比较差异无统计学意义(P>0.05)。结论:有复发性流产史妊娠期妇女小剂量阿司匹林的临床应用效果好。

Objective:To study the clinical effect of low-dose Aspirin in pregnant women with recurrent abortion history.Method:A total of 100 cases of pregnant women with history of recurrent abortion in our hospital from January 2018 to January 2020 were retrospectively selected and divided into low-dose Aspirin combined with Low-molecular-weight Heparin Sodium treatment group (combined treatment group,n=50) and single Low-molecular-weight Heparin Sodium treatment group (single treatment group,n=50) according to the treatment methods.The hormone levels,immune functions and pregnancy protection success,incidences of adverse reactions of the two groups were statistically analyzed.Result:The increases of levels of serum E2,P and hCG of the combined treatment group were significantly higher than the single treatment group (P<0.05).The increase of serum IL-4 level,decreases of serum IFN-γ level and IFN-γ/IL-4 of the combined treatment group were significantly higher than single treatment group (P<0.05).In terms of success rate of fetal preservation,88.0% (44/50) in the combined treatment group and 56.0% (28/50) in the single treatment group,the former was significantly higher than the latter (P<0.05).The incidence of adverse reactions was 2.0% (1/50) in the combined treatment group and 6.0% (3/50) in the single treatment group,the difference between the two groups was not significant (P>0.05).Conclusion:The clinical effect of low-dose Aspirin in pregnant women with recurrent abortion history is good.