硫酸镁联合氨溴索雾化吸入治疗小儿支气管哮喘急性发作的效果及对血气指标的影响

Effect of Magnesium Sulfate Combined with Ambroxol atomization inhalation in the Treatment of Acute Attack of Bronchial Asthma in Children and Its Influence on Blood Gas Indexes

目的:探讨硫酸镁联合氨溴索雾化吸入治疗小儿支气管哮喘(BA)急性发作的效果及对血气指标的影响。方法:选取2018年1月-2020年6月本院的小儿BA急性发作患者200例。随机分为研究组(n=100)与对照组(n=100)。对照组给予氨溴索雾化吸入治疗,研究组给予硫酸镁联合氨溴索雾化吸入治疗,比较两组临床疗效、治疗前后血气分析指标[动脉血二氧化碳分压(PaCO_(2))、动脉血氧分压(PaO_(2))]、各症状缓解时间、C反应蛋白(CRP)和白细胞计数(WBC)水平。结果:治疗前,两组PaCO_(2)、PaO_(2)、CRP和WBC水平比较差异无统计学意义(P>0.05)。治疗后,研究组治疗总有效率、PaO_(2)水平明显高于对照组,各症状缓解时间明显早于对照组,PaCO_(2)、CRP和WBC水平明显低于对照组(P<0.05)。结论:硫酸镁联合氨溴索雾化吸入治疗小儿BA急性发作的临床效果显著,可改善其血气指标。

Objective:To investigate the effect of Magnesium Sulfate combined with Ambroxol aerosol inhalation in the treatment of acute attack of bronchial asthma (BA) in children and its influence on blood gas indexes.Method:A total of 200 children with acute attack of BA in our hospital from January 2018 to June 2020 were selected and randomly divided into the study group (n=100) and the control group (n=100).The control group was given Ambroxol atomization inhalation,and the study group was given Magnesium Sulfate combined with Ambroxol atomization inhalation.The clinical efficacy,blood gas analysis indexes[arterial partial pressure of carbon dioxide (PaCO_(2)),arterial partial pressure of oxygen (PaO_(2))]before and after treatment,symptom relief time,C-reactive protein (CRP) and white blood cell count (WBC) levels were compared between the two groups.Result:Before treatment,there were no significant differences in levels of PaCO_(2),PaO_(2),CRP and WBC between the two groups (P>0.05).After treatment,the total effective rate of PaO_(2) in the study group was significantly higher than that in the control group,the symptom srelief time was significantly earlier than that in the control group,and the levels of PaCO_(2),CRP and WBC were significantly lower than that in the control group (P<0.05).Conclusion:Magnesium Sulfate combined with Ambroxol aerosol inhalation in the treatment of acute attack of BA in children has significant clinical effect,which can improve the blood gas indexes.