痛风患者发生肾结石的影响因素

Influence Factors of the Occurrence of Kidney Stones in Patients with Gout

目的:探讨痛风患者发生肾结石的影响因素。方法:选择2018年5月-2020年5月本院收治的90例痛风患者。所有患者均接受多普勒彩色超声检查,将并发肾结石患者纳入发生组,未发生肾结石患者纳入未发生组。比较两组一般资料,并将单因素分析结果中差异有统计学意义的因素纳入自变量并赋值,采用多因素Logistic回归分析痛风患者发生肾结石的影响因素。结果:90例痛风患者经多普勒彩色超声诊断后,确诊肾结石26例,发生率为28.89%(26/90)。单因素分析结果显示,两组体质量指数(BMI)、低密度脂蛋白(LDL)、有无高血压比较差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,BMI≥24 kg/m^(2)、合并高血压、LDL高表达均是痛风患者发生肾结石的危险因素(OR>1,P<0.05)。结论:BMI≥24 kg/m^(2)、合并高血压、LDL高表达均会增加痛风患者并发肾结石风险,临床应评估患者是否伴肾结石风险因素,针对存在风险者应积极采取干预,以降低患者并发肾结石风险。

Objective:To investigate the influence factors of the occurrence of kidney stones in patients with gout.Method:A total of 90 gout patients treated in our hospital from May 2018 to May 2020 were selected.All patients underwent Doppler color ultrasound examination,patients with concurrent kidney stones were included in the occurrence group,and patients without kidney stones were included in the non-occurrence group.The general data of two groups were compared,and the factors with statistically significant differences in the univariate analysis results were included into the independent variables and assigned values.Multivariate Logistic regression was used to analyze the influencing factors for the occurrence of renal stones in patients with gout.Result:After the diagnosis of 90 patients with gout by Doppler color ultrasound,26 cases were diagnosed with kidney stones,the incidence rate was 28.89% (26/90).Univariate analysis showed that there were statistically significant differences between the two groups in the body mass index (BMI),low-density lipoprotein (LDL) and presence or absence of hypertension (P<0.05).The results of multivariate Logistic regression analysis showed that both BMI>24 kg/m^(2),complicated hypertension and high expression of LDL were risk factors for kidney stones in patients with gout (OR>1,P<0.05).Conclusion:Patients with BMI≥24 kg/m^(2),complicated hypertension,and high LDL expression are at increased risk of concurrent kidney stones in patients with gout,and should be assessed clinically for kidney stone risk factors,with interventions aimed at those at risk being aggressive to reduce the risk of concurrent kidney stones.