无创正压通气在慢性阻塞性肺疾病急性加重期呼吸衰竭患者中的应用及对血气指标的改善作用

Application of Noninvasive Positive Pressure Ventilation in the Treatment of Patients with Chronic Obstructive Pulmonary Disease Acute Exacerbation Respiratory Failure and the Improvement of Blood Gas Indexes

目的:探讨对慢性阻塞性肺疾病(COPD)急性加重期呼吸衰竭患者予以无创正压通气治疗的应用效果,以及对其血气相关指标的改善作用。方法:选取2017年1月-2020年6月本院收治的150例COPD急性加重期呼吸衰竭患者,随机将其分为对照组(n=68)与观察组(n=82)。对照组予以常规疗法,观察组基于常规疗法联合无创正压通气治疗。观察两组临床治疗效果,检测两组治疗前后动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))、脑钠肽(NT-proBNP)水平。结果:观察组治疗总有效率为98.78%,高于对照组的86.76%(P<0.05)。治疗前,两组PaO_(2)、PaCO_(2)、NT-proBNP水平比较差异无统计学意义(P>0.05);治疗后,观察组PaO_(2)、PaCO_(2)、NT-proBNP水平明显优于对照组(P<0.05)。结论:临床针对COPD急性加重期呼吸衰竭患者予以无创正压通气治疗,能改善其动脉血气指标,缓解其临床症状,提高临床治疗效果,对促进病情早日康复具有积极作用。

Objective:To investigate the application effect of noninvasive positive pressure ventilation in the treatment of patients with chronic obstructive pulmonary disease(COPD)acute exacerbation respiratory failure,and the improvement of blood gas indexes.Method:A total of 150 COPD patients with acute exacerbation of respiratory failure in our hospital from January 2017 to June 2020 were selected and randomly divided into the control group(n=68)and the observation group(n=82).The control group was given conventional therapy,the observation group was based on conventional therapy combined with noninvasive positive pressure ventilation.The clinical treatment effect of the two groups was observed,and the levels of arterial partial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2)),brain natriuretic peptide(NT-proBNP)before and after treatment were detected.Result:The total effective rate of the observation group was 98.78%,which was higher than 86.76%of the control group(P<0.05).Before treatment,there were no significant differences in PaO_(2),PaCO_(2),NT-proBNP levels between the two groups(P>0.05);after treatment,the PaO_(2),PaCO_(2),NT-proBNP levels in the observation group were significantly better than those in the control group(P<0.05).Conclusion:Noninvasive positive pressure ventilation for patients with COPD with acute exacerbation respiratory failure canimprove the arterial blood gas indexes,relieve the clinical symptoms,improve the clinical treatment effect and has positive effect on promoting the early recovery of the disease.