普拉克索联合多巴丝肼治疗帕金森病的效果及对脑血流量的影响

Effect of Pramipexole Combined with Levodopaand Benserazide in the Treatment of Parkinson Disease and Its Influence on Cerebral Blood Flow

目的:探讨普拉克索联合多巴丝肼治疗帕金森病的效果及对脑血流量(CBF)的影响。方法:将2017年6月-2020年5月本院收治的76例帕金森病患者随机分为对照组(n=38)和研究组(n=38)。对照组单独予多巴丝肼治疗,研究组联合应用普拉克索及多巴丝肼治疗。比较两组临床治疗效果及CBF。结果:研究组治疗总有效率(86.84%)较对照组(63.16%)明显更高(P<0.05);治疗后,两组CBF均较治疗前升高,研究组脑血流量高于对照组(P<0.05)。结论:联合应用普拉克索及多巴丝肼临床治疗帕金森病,效果显著,可有效改善患者脑部循环,并增加脑血流量,值得推广。

Objective:To investigate the effect of Pramipexole combined with Levodopaand Benserazide in the treatment of Parkinson disease and its influence on cerebral blood flow(CBF).Method:A total of 76 patients with Parkinson disease admitted to our hospital from June 2017 to May 2020 were randomly divided into the control group(n=38)and the study group(n=38).The control group was treated with Levodopaand Benserazide alone,the study group was treated with Pramipexole and Levodopaand Benserazide.The clinical effect and CBF of the two groups were compared.Result:The total effective rate of the study group(86.84%)was significantly higher than 63.16%of the control group(P<0.05);after treatment,the CBF of the two groups were improved than that before treatment,and the CBF of the study group was significantly higher than that of the control group(P<0.05).Conclusion:The combined application of Pramipexole and Levodopaand Benserazide in the clinical treatment of Parkinson disease has a significant effect,which can effectively improve the brain circulation and increase cerebral blood flow,and is worthy of promotion.