布地奈德福莫特罗对咳嗽变异性哮喘患者肺功能及血清IL-4、TNF-α水平的影响

Effect of Budesonide Formoterol on Lung Function and Serum Levels of IL-4 and TNF-αin Patients with Cough Variant Asthma

目的:研究布地奈德福莫特罗对咳嗽变异性哮喘患者肺功能及血清IL-4、TNF-α水平的影响。方法:选取2017年5月-2020年7月笔者所在医院收治的120例咳嗽变异性哮喘患者作为研究对象,按照随机数字表法将其分为对照组和研究组,每组60例。对照组给予孟鲁司特钠口服治疗,研究组在对照组基础上给予布地奈德福莫特罗吸入粉雾剂治疗,两组均持续治疗3个月。比较两组临床疗效、治疗前后FVC、PEF、FEV_(1)/FVC水平及血清白介素-4(IL-4)、肿瘤坏死因子-α(TNF-α)水平。结果:治疗后,研究组临床总有效率为93.33%,高于对照组的70.00%,差异有统计学意义(P<0.05);治疗后,两组FVC、PEF、FEV_(1)/FVC水平均较治疗前升高,且研究组高于对照组,差异有统计学意义(P<0.05);治疗后,两组血清IL-4、TNF-α水平均较治疗前降低,且研究组低于对照组,差异有统计学意义(P<0.05)。结论:布地奈德福莫特罗治疗咳嗽变异性哮喘,可显著提高临床疗效,改善患者肺功能水平,降低患者血清IL-4、TNF-α水平,值得临床进一步研究和推广应用。

Objective:To investigate the effects of Budesonide Formoterol on lung function and serum levels of IL-4 and TNF-αin patients with cough variant asthma.Method:A total of 120 patients with cough variant asthma admitted in our hospital from May 2017 to July 2020 were selected as the research subjects.They were divided into the control group and the research group according to the random number table method,with 60 patients in each group.The control group was treated with Montelukast Sodium orally,and the research group was treated with Budesonide and Formoterol Fumarate Powder for Inhalation on the basis of the control group.Both groups were treated continuously for 3 months.The clinical efficacy,the levels of FVC,PEF,FEV_(1)/FVC and serum interleukin-4(IL-4)and tumor necrosis factor-α(TNF-α)before and after treatment were compared between the two groups.Result:After treatment,the clinical total effective rate of the research group was 93.33%,which was higher than 70.00%of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of FVC,PEF and FEV_(1)/FVC in both groups were increased than those before treatment,and those in the research group were higher than those in the control group,the differences were statistically significant(P<0.05).After treatment,the serum IL-4 and TNF-αlevels in both groups were decreased than those before treatment,and those in the research group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Budesonide Formoterol in the treatment of cough variant asthma can significantly improve the clinical efficacy,improve the level of lung function of patients,reduce the levels of serum IL-4 and TNF-α,which is worthy of further clinical research and application.