自拟益气强心膏在慢性心力衰竭心室重构中的抑制作用

The inhibitory effect of the Yiqi Qiangxin cream on ventricular remodeling in chronic heart failure patients

目的:研究自拟益气强心膏对慢性心力衰竭心室重构的抑制作用。方法:将2019年3月-2020年3月至惠州市中医医院诊疗的60例慢性心力衰竭患者纳入研究。按照随机分组法,将入组的60例患者分为对照组(30例)、膏方组(30例),对照组使用西医常规抗心力衰竭治疗方案,膏方组则在对照组的基础上加上自拟的膏方治疗,观察两组患者治疗前后明尼苏达生活质量评分、6 min步行距离试验(6-minute Walk Test,6MWT),心脏超声指标[左室射血分数(Left Ventricular Ejection Fractions,LVEF)、每搏输出量(Stroke Volume,SV)、心脏指数(Cardiac Index,CI)]及心力衰竭指标B型利钠肽(B-type Natriuretic Peptide,BNP)和心室重构标志因子几丁质酶3样蛋白1(Chitinase 3 Like Protein 1,CHl3L1)、基质金属蛋白酶9(Matrix Metalloproteinase 9,MMP9)的水平。结果:两组患者在治疗完成后,明尼苏达生活质量评分、6MWT、心脏超声指标、心力衰竭指标、心室重构标志物等观察指标均比治疗前好转,而膏方组患者6MWT、心脏超声指标、BNP、CHl3L1、MMP9均较对照组改善更为明显(P<0.05)。结论:自拟益气强心膏能够抑制慢性心力衰竭患者的心室重构,值得临床推广和应用。

Objective:To explore the inhibitory effect of the Yiqi Qiangxin cream(益气强心膏)on ventricular remodeling in chronic heart failure patients.Methods:60 patients were divided into the control group and the cream group,30 cases in each.The control group was given conventional anti-heart failure treatment.The cream group was given the Yiqi Qiangxin cream more.Results:After the treatment,the observation indicators in the two groups were better than before,and Minnesota Living masks,the 6MWT,left ventricular ejection fraction,BNP,CHl3L1,and MMP9 in the cream group were more improved than the control group.Conclusion:The Yiqi Qiangxin cream can inhibit ventricular remodeling in patients with chronic heart failure,and is worthy of promotion.