格列美脲联合二甲双胍治疗老年糖尿病的效果分析

Analysis of the effect of glimepiride combined with metformin in the treatment of senile diabetes mellitus

目的探讨格列美脲联合二甲双胍治疗老年糖尿病的临床效果。方法90例老年糖尿病患者,以治疗方法不同分为常规组和实验组,各45例。常规组予以格列美脲治疗,实验组给予格列美脲联合二甲双胍治疗。比较两组临床疗效、用药治疗过程中不良反应发生情况、糖代谢指标、脂代谢指标及生活质量评分。结果实验组总有效率95.6%显著高于常规组的80.0%,差异具有统计学意义(P<0.05)。治疗后,实验组空腹血糖(FPG)(6.40±1.07)mmol/L、餐后2 h血糖(2 h PG)(9.04±1.41)mmol/L及糖化血红蛋白(HbA1c)(5.38±1.04)%均低于常规组的(7.28±1.32)mmol/L、(10.14±1.72)mmol/L、(6.92±1.25)%,差异具有统计学意义(P<0.05)。治疗后,实验组总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)及甘油三酯(TG)分别为(3.62±0.42)、(2.26±0.40)、(1.62±0.25)mmol/L,均低于常规组的(4.58±0.67)、(3.11±0.45)、(2.20±0.41)mmol/L,差异具有统计学意义(P<0.05)。实验组不良反应发生率为4.4%,略低于常规组的6.7%,但差异无统计学意义(P>0.05)。实验组躯体功能、生活状态、社会功能及心理功能评分分别为(84.33±6.96)、(82.29±6.02)、(82.14±4.53)、(81.93±4.55)分,均高于常规组的(75.20±5.99)、(73.54±4.23)、(76.25±4.06)、(74.08±4.44)分,差异具有统计学意义(P<0.05)。结论以格列美脲联合二甲双胍治疗老年糖尿病患者,不仅能够改善患者血糖水平及体内脂代谢紊乱程度,还能有效提高患者生活质量,安全性较高。

Objective To discuss the clinical effect of glimepiride combined with metformin in the treatment of senile diabetes mellitus.Methods A total of 90 senile patients with diabetes mellitus were divided into conventional group and experimental group according to different treatment methods,with 45 cases in each group.The conventional group was treated with glimepiride,and the experimental group was treated with glimepiride and metformin.The clinical efficacy,occurrence of adverse reactions during treatment,glucose metabolism index,lipid metabolism index and quality of life score were compared between the two groups.Results The total effective rate 95.6%of the experimental group was significantly higher than 80.0%of the conventional group,and the difference was statistically significant(P<0.05).After treatment,the fasting plasma glucose(FPG)(6.40±1.07)mmol/L,2 h postprandial glucose(2 h PG)(9.04±1.41)mmol/L and glycosylated hemoglobin(HbA1c)(5.38±1.04)%of the experimental group were lower than(7.28±1.32)mmol/L,(10.14±1.72)mmol/L and(6.92±1.25)%of the conventional group,and the difference was statistically significant(P<0.05).After treatment,the total cholesterol(TC),low density lipoprotein cholesterol(LDL-C)and triglyceride(TG)of the experimental group were(3.62±0.42),(2.26±0.40)and(1.62±0.25)mmol/L,which were lower than(4.58±0.67),(3.11±0.45)and(2.20±0.41)mmol/L of the conventional group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions 4.4%of the experimental group was a little lower than 6.7%of the conventional group,but the difference was not statistically significant(P>0.05).The scores of physical function,life state,social function and mental function of the experimental group were(84.33±6.96),(82.29±6.02),(82.14±4.53)and(81.93±4.55)points,which were higher than(75.20±5.99),(73.54±4.23),(76.25±4.06)and(74.08±4.44)points of the conventional group,and the difference was statistically significant(P<0.05).Conclusion Combination of glimepiride and metformin can not only improve the patient’s blood glucose level and the degree of lipid metabolism disorder,but also effectively improve the patient’s quality of life with high safety.