银杏达莫注射液联合依达拉奉对缺血性脑梗死患者血液流变学及MMP-2、MMP-9水平的影响

Effects of ginkgo leaf extract and dipyridamole injection combined with edaravone on hemorheology and MMP-2 and MMP-9 levels in patients with ischemic cerebral infarction

目的探讨银杏达莫注射液联合依达拉奉对缺血性脑梗死患者血液流变学及基质金属蛋白酶2(MMP-2)、基质金属蛋白酶9(MMP-9)水平的影响。方法80例缺血性脑梗死患者,根据随机数字表法分为对照组与观察组,各40例。对照组在基础治疗上加用依达拉奉注射液治疗,观察组在对照组基础上加银杏达莫注射液治疗。比较两组患者临床效果以及治疗前后血液流变学、MMP-9水平、MMP-2水平。结果观察组治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组患者全血低切黏度(LSV)、全血高切黏度(HSV)、血浆黏度(PSV)、血浆纤维蛋白原(FIB)水平分别为(9.52±1.02)mPa·s、(4.58±0.52)mPa·s、(2.23±0.21)mPa·s、(2.36±0.47)g/L,均低于对照组的(10.63±1.85)mPa·s、(5.84±0.87)mPa·s、(3.01±0.47)mPa·s、(3.31±0.86)g/L,差异均具有统计学意义(P<0.05)。观察组MMP-2为(186.63±10.25)μg/L低于对照组的(205.96±12.74)μg/L,MMP-9(194.15±11.36)μg/L低于对照组的(215.71±11.89)μg/L,差异均具有统计学意义(t=7.477、8.292,P<0.05)。结论银杏达莫注射液联合依达拉奉治疗缺血性脑梗死效果满意,可改善血液流变学指标,调节MMP-2与MMP-9水平,值得推广。

Objective To discuss the effects of ginkgo leaf extract and dipyridamole injection combined with edaravone on hemorheology and matrix metalloproteinase 2(MMP-2)and matrix metalloproteinase 9(MMP-9)levels in patients with ischemic cerebral infarction.Methods A total of 80 patients with ischemic cerebral infarction were divided into control group and observation group according to random numerical table,with 40 cases in each group.The control group was treated with edaravone injection on the basis of the control group,and the observation group was treated with ginkgo leaf extract and dipyridamole injection based on the control group.The clinical effect,hemorheology,MMP-9 level,MMP-2 level before and after treatment were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the whole blood low shear viscosity(LSV),whole blood high shear viscosity(HSV),plasma viscosity(PSV),plasma fibrinogen(FIB)of the observation group were(9.52±1.02)mPa·s,(4.58±0.52)mPa·s,(2.23±0.21)mPa·s,(2.36±0.47)g/L,which were lower than(10.63±1.85)mPa·s,(5.84±0.87)mPa·s,(3.01±0.47)mPa·s,(3.31±0.86)g/L of the control group,and the difference was statistically significant(P<0.05).The MMP-2(186.63±10.25)μg/L of the observation group was lower than(205.96±12.74)μg/L of the control group,and MMP-9(194.15±11.36)μg/L was lower than(215.71±11.89)μg/L of the control group.All the difference was statistically significant(t=7.477,8.292;P<0.05).Conclusion Combination of ginkgo leaf extract and dipyridamole injection and edaravone has satisfactory results in the treatment of ischemic cerebral infarction,which can improve hemorheological indexes and regulate the levels of MMP-2 and MMP-9,which is worthy of promotion.