乙肝肝硬化患者D-D、MPV、PDW、AFP-L3、GP-73的变化与HBV-DNA的关系

Relationship between changes of D-D,MPV,PDW,AFP-L3 and GP-73 and HBV-DNA in patients with hepatitis B cirrhosis

目的:探讨乙肝肝硬化患者D-二聚体(D-D)、平均血小板体积(MPV)、血小板分布宽度(PDW)、甲胎蛋白L3(AFP-L3)、高尔基体蛋白-73(GP-73)的变化及与乙肝病毒载量(HBV-DNA)的关系。方法:选取我院2017年1月至2017年12月确诊的90例乙肝肝硬化患者(肝硬化组)、90例乙肝病毒感染但是未发生肝硬化的患者作为乙肝组,检测并对比两组的患者的D-D、MPV、PDW、AFP-L3、GP-73指标,并根据HBV-DNA将肝硬化患者进行分层对比,分析D-D、MPV、PDW、AFP-L3、GP-73与HBV-DNA的相关性。结果:肝硬化组患者的D-D、MPV、PDW、AFP-L3、GP-73测定值显著的高于乙肝组,差异均具有统计学意义;高载量组肝硬化患者的D-D、MPV、PDW、AFP-L3、GP-73测定值显著的高于中载量组和低载量组,差异均具有统计学意义;中载量组肝硬化患者的D-D、PDW、AFP-L3、GP-73测定值显著的高于低载量组,差异均具有统计学意义;乙肝肝硬化患者的D-D、AFP-L3、GP-73与HBV-DNA呈显著的正相关关系,乙肝肝硬化患者的HBV-DNA水平与MPV、PDW无相关关系。结论:乙肝肝硬化患者的D-D、MPV、PDW、AFP-L3、GP-73测定值较单纯肝硬化患者显著的升高,D-D、AFP-L3、GP-73能在一定程度上间接反应乙肝病毒的复制情况。

Objective The changes in D-two polymer(D-D),average platelet volume(MPV),platelet distribution width(PDW),alpha fetoprotein L3(AFP-L3),Golgi protein-73(GP-73)and the relationship with HBV load(HBV-DNA)in patients with hepatitis B liver cirrhosis were investigated.Methods 90 patients with hepatitis B cirrhosis(liver cirrhosis)and 90 cases of hepatitis B virus infection in our hospital from January 2017 to December 2017 were selected as the hepatitis B group.The D-D,MPV,PDW,AFP-L3 and GP-73 indexes of the two groups were measured and compared,and the patients with cirrhosis were stratified by HBV-DNA according to HBV-DNA.The correlation between D-D,MPV,PDW,AFP-L3,GP-73 and HBV-DNA was analyzed.Results The values of D-D,MPV,PDW,AFP-L3 and GP-73 in the patients with liver cirrhosis were significantly higher than those in the hepatitis B group,and the difference was statistically significant.The values of D-D,MPV,PDW,AFP-L3 and GP-73 were significantly higher in the patients with high load liver cirrhosis than in the medium and low load groups,and the difference was statistically significant.The values of D-D,PDW,AFP-L3 and GP-73 in the patients with liver cirrhosis were significantly higher than those in the low load group,and the difference was statistically significant.The D-D,AFP-L3,GP-73 and HBV-DNA in the patients with hepatitis B cirrhosis had a significant positive correlation.There was no correlation between the HBV-DNA level of the patients with hepatitis B cirrhosis and MPV.Conclusion The values of DD,MPV,PDW,AFP-L3 and GP-73 in patients with hepatitis B cirrhosis were significantly higher than those in patients with cirrhosis.DD,AFP-L3 and GP-73 could indirectly reflect the replication of hepatitis B virus to some extent.Happening.