氨溴索联合多巴胺治疗新生儿感染性肺炎的疗效评价

Evaluation on the therapeutic effects of Ambroxol combined with Dopamine in the treatment of neonatal infectious pneumonia

目的:分析氨溴索联合多巴胺治疗新生儿感染性肺炎(NIP)的疗效,为合理制订临床治疗方案提供研究依据。方法:选取2017年1月~2019年1月的202例NIP患儿作为研究对象,应用随机数字表法将其分为研究组和对照组,每组各101例。对照组患儿在常规对症治疗基础上给予盐酸氨溴索静脉滴注,研究组患儿在对照组疗法基础上加用多巴胺静脉滴注,两组患者均连续治疗7d。对两组患儿的呼吸困难缓解时间、喘息消失时间、咳嗽消失时间、肺部啰音消失时间、住院时间进行记录和对比。对两组患儿治疗前、后的血清清白细胞介素(IL)-2、IL-6、IL-10、心肌酶谱指标水平及外周血血小板计数(PLT)、血小板压积(PCT)、血小板分布宽度(PDW)、平均血小板体积(MPV)等血小板参数指标进行检测和比较。结果:研究组患儿的呼吸困难缓解时间、喘息消失时间、咳嗽消失时间、肺部啰音消失时间、住院时间均短于对照组,差异均有统计学意义。经治疗后,两组患儿的血清IL-2及PLT水平均较治疗前上升,血清IL-6、IL-10、心肌酶谱指标水平及PCT、PDW、MPV水平均较治疗前下降,差异均有统计学意义,研究组患儿治疗前、后的上述指标的差值均高于对照组,差异均有统计学意义。结论:与应用氨溴索治疗相比较,联合应用氨溴索和多巴胺对NIP患儿进行治疗,能够快速缓解患儿的主要临床症状,降低炎症反应程度,改善心肌酶谱指标和血小板参数指标,有利于提高治疗效果,改善患儿的预后。

Objective To analyze the therapeutic effects of Ambroxol combined with Dopamine in the treatment of neonatal infectious pneumonia(NIP)to provide research basis for rational formulation of clinical treatments.Methods 202 children with NIP from January of 2017 to January of 2019 were selected as the study subjects.They were divided into the study group and the control group by random number table method,101 cases were included into each group.The children in the control group were treated with intravenous drip of Ambroxol Hydrochloride on the basis of routine symptomatic treatments,while the children in the study group were treated with intravenous drip of Dopamine Hydrochloride on the basis of the therapy of the control group.The children in both groups were treated continuously for 7 days.The time for dyspnea remission,the time for wheezing disappearance,the time for cough disappearance,the time for lung rale disappearance,the hospitalization time between the children in the two groups were recorded and compared.The levels of serum interleukin(IL)-2,IL-6,IL-10,myocardial enzymogram indicators and the platelet parameters such as platelet count(PLT),plateletcrit(PCT),platelet distribution width(PDW),mean platelet volume(MPV)in the peripheral blood before and after the treatments between the patients in the two groups were measured and compared.Results The time for dyspnea remission,the time for wheezing disappearance,the time for cough disappearance,the time for lung rale disappearance,the hospitalization time of the children in the study group were shorter than those in the control group,the differences were statistically significant.After the treatments,the serum IL-2 levels and the PLT levels of the children in the two groups were higher than those before the treatments,the serum IL-6,IL-10 levels,the serum myocardial enzymogram indicators levels and the PCT,PDW,MPV levels were lower than those before the treatments,the differences were statistically significant.The differences of the above indicators between before and after the treatment of the children in the study group were higher than those in the control group,the differences were statistically significant.Conclusion Compared with the application of Ambroxol,the combination application of Ambroxol and Dopamine can quickly relieve the main clinical symptoms,reduce the degree of inflammations,improve the myocardial enzymogram indicators and the platelet parameters in NIP children,which is benefit to improve the therapeutic effects and prognosis.