急性缺血性脑卒中患者卒中后抑郁发病率与危险因素分析

Risk factors and incidence rate of post-stroke depression in patients with acute ischemic stroke

目的:调查分析急性缺血性脑卒中患者卒中后抑郁(PSD)发病率与危险因素。方法:选择2018年9月~2020年6月在第921医院神经内科治疗的老年急性缺血性脑卒中患者298例为研究对象。收集患者的人口学资料、临床资料,统计分析PSD的发病率及危险因素。结果:298例急性缺血性脑卒中患者共有75例(33.6%)发生卒中后抑郁。根据患者有无抑郁分为卒中后抑郁组(PSD组)和非卒中后抑郁组(N-PSD组),两组患者的NIHSS评分、BI指数评分、身份类型、早期依达拉奉使用情况、血清白蛋白有显著差异,差异具有统计学意义。单因素logistic回归分析显示:血清白蛋白、入院时NIHSS评分、BI指数评分、干部身份、早期依达拉奉使用是PSD发生的危险因素。多因素logistic回归分析显示:干部身份、早期未使用依达拉奉、入院时高NIHSS评分、低BI指数评分是PSD发病的独立危险因素。结论:急性缺血性脑卒中患者卒中后抑郁发生率较高,干部身份、早期未使用依达拉奉、入院时高NIHSS评分、低BI指数评分是PSD发病的独立危险因素。

Objective To research and analysis the risk factors and incidence rate of post-stroke depression(PSD)in patients with acute ischemic stroke.Methods 298 patients withs elderly acute ischemic stroke admitted to the Department of Neurology Medicine at the 921 Hospital from September 2018 to June 2020 were selected as the study subjects.The demographic date and clinical date of patients were collected,and then the incidence rate and risk factors of PSD were analyzed.Results A total of 75 of 298 acute ischemic stroke patients developed poststroke depression.They were devided into PSD group and non-PSD group,according to whether they had depression or not.There were significant differences in NIHSS score,BI index score,identity types,early use of edaravone,serum albumin between the two groups.The difference was statistically significant.The results of single factor logistic regression analysis showed that serum albumin,NIHSS score at admission,BI index score,the cadre identity and early use of edaravone were the risk factors of PSD.The multivariate logistic regression analysis showed that the cadre identity,edaravone was not in the early days,high NIHSS score at admission,low BI index score were the independent risk factors of PSD.Conclusion The incidence of PSD in the acute ischemic stroke patients is higher.The cadre indentity,edaravone was not used in the early days,high NIHSS score at admission,low BI index score ara independent risk factors of PSD.