不同剂量乌司他丁对感染性休克治疗效果比较及对患者血清ALT、AST、Lac的影响

Study on the efficiency of ulinastatin with different doses in the treatment process of septic shock and the effect on the ALT、AST、Lac in serum

目的:探讨不同剂量乌司他丁对感染性休克的治疗效果及对患者血清ALT、AST、Lac的影响。方法:本文研究对象为我院收治的100例感染性休克患者,根据其临床病例资料分为观察组与对照组。观察组患者使用高剂量乌司他丁进行治疗(n=52),而对照组患者使用常规剂量乌司他丁进行治疗(n=48)。对比研究两组患者的治疗效果。结果:治疗后(1h、4h、12h、24h、72h),观察组HR明显低于对照组,而SBP、每小时尿量明显高于对照组。治疗后,观察组炎性指标值及APACHE Ⅱ评分、呼吸频率明显小于对照组,而体温差别不明显。观察组患者恢复时间、住院天数以及MODS发生率、病死率均明显小于对照组,且观察组患者总体生存期明显高于对照组患者。治疗后,观察组血清ALT、AST、Lac水平明显低于对照组。结论:相比较常规剂量,大剂量乌司他丁能明显增加感染性休克患者尿量及血压,并降低患者炎性反应及血清ALT、AST、Lac水平,提高生存质量,疗效显著。因此,该方法值得推荐。

Objective To study on the efficiency of ulinastatin with different doses in the treatment process of septic shock and the effect on the ALT、AST、Lac in serum.Methods The 100 patients with septic shock were treated in our hospital,They were considered as study objects and the clinical data were analyzed retrospectively.They were divided into observation group(n=52)and control group(n=48).The patients were treated with ulinastatin with higher dose in the observation group,while the patients were treated with ulinastatin with regular dose in the control group.The treatment effects were observed and compared.Results After treatment(1h,4h,12h,24h,72h),the HR of the observation group was significantly lower than that of the control group,while the SBP and urine output per hour were significantly higher than that of the control group.After treatment,the inflammatory index values,APACHE Ⅱ score,and respiratory rate of the observation group were significantly lower than those of the control group,but the difference in body temperature was not significant.The recovery time,hospitalization days,MODS incidence and mortality of the observation group were significantly lower than those of the control group,and the overall survival time of the observation group was significantly higher than that of the control group.After treatment,the serum ALT,AST and Lac levels of the observation group were significantly lower than those of the control group.Conclusion Compared with the regular dose,ulinastatin with higher dose is used to treat septic shock,it can obviously increase the urinary production and blood pressure,reducing the inflammatory response and the levels of ALT,AST and Lac in serum level and improving the quality of life.The treatment effect is significant and this method is recommended in clinical.