心理联合利培酮治疗抽动秽语综合征的效果观察

Comparison of psychotherapy combined with risperidone and haloperidol in treatment of Tourette's syndrome

目的探讨心理联合利培酮治疗抽动秽语综合征的临床疗效。方法将60例抽动秽语综合征患者随机分为对照组和观察组各30例,对照组给予氟哌啶醇及心理治疗,观察组给予利培酮及心理治疗,经4周治疗后采用耶鲁综合抽动严重程度量表(YGTSS)评估两组的疗效,并观察不良反应情况。结果观察组的治疗有效率93.33%优于对照组的70.00%,差异有统计学意义(P<0.05)。治疗后,两组的YGTSS评分均有下降,与治疗前比较差异具有统计学意义(均P<0.05);而且观察组治疗后的YGTSS评分明显低于对照组,差异有统计学意义(t=3.2255,P=0.0021)。两组的不良反应比较,差异无统计学意义(P>0.05)。结论利培酮联合心理治疗抽动秽语综合征较氟哌啶醇联合心理治疗的效果好,值得临床推广应用。

Objective To explore the effect of psychotherapy combined with risperidone on Tourette syndrome.Methods 60 patients with Tourette's syndrome were randomly divided into the control group and the observation group,30 cases in each group.The control group was treated with haloperidol and psychotherapy,and the observation group was treated with risperidone and psychotherapy.After 4 weeks of treatment,the Yale Tourette's syndrome severity scale(YGTSS)was used to evaluate the curative effect of the two groups and observe the adverse reactions.Results(1)the total effective rates of the control group and the observation group were 70.00%and 93.33%,respectively,with statistical significance(P<0.05).After treatment,YGTSS scores of the two groups decreased,with significant difference compared with before treatment(P<0.05);after treatment,YGTSS score of the observation group was lower than that of the control group,with significant difference(t=3.2255,P=0.0021).(3)There was no significant difference in the incidence of adverse drug reactions between the two groups(P>0.05).Conclusion The effect of psychotherapy combined with risperidone in the treatment of Tourette syndrome is better than psychotherapy combined with haloperidol,which is worthy of clinical promotion.