孟鲁司特钠辅助治疗小儿反复发作性过敏性紫癜的临床疗效

Clinical effect of montelukast sodium in adjuvant treatment of recurrent allergic purpura in children

目的观察孟鲁司特钠辅助治疗小儿反复发作性过敏性紫癜的临床疗效。方法选取2017年1月-2019年2月于湖南省湘潭市中心医院儿科接受治疗的反复发作性过敏性紫癜患儿60例,采用随机数字表法分为试验组和对照组各30例。对照组患儿予以常规治疗,试验组患儿在常规治疗的基础上予以孟鲁司特钠治疗。比较2组临床疗效、治疗前后炎性因子水平及生化检查结果,跟踪随访1年,比较2组复发情况。结果试验组总有效率为96.67%,高于对照组的76.67%(χ^(2)=5.192,P=0.023);治疗后,2组IL-16、IL-18水平均低于治疗前,且试验组低于对照组(P<0.01);治疗后,2组Ig G、TRF、Alb水平均低于治疗前,且试验组低于对照组(P<0.05或P<0.01);随访1年,试验组复发率为6.67%,低于对照组的26.67%(χ^(2)=4.320,P=0.038)。结论在常规治疗基础上予以孟鲁司特钠治疗小儿反复发作性过敏性紫癜可有效减轻患儿体内炎性反应,改善尿生化指标,减少疾病复发,减轻患儿痛苦,治疗效果较好,值得推广。

Objective To observe the clinical efficacy of montelukast sodium in adjuvant treatment of children with recurrent allergic purpura.Methods Selected 60 children with recurrent allergic purpura who were treated in the Department of Pediatrics,Xiangtan Central Hospital,Hunan Province from January 2017 to February 2019.Using random number table method,they were divided into experimental group and control group with 30 cases each.Children in the control group were given conventional treatment,and children in the experimental group were treated with montelukast sodium on the basis of conventional treatment.The clinical efficacy,inflammatory factor levels and biochemical examination results before and after treatment were compared between the two groups,followed up for 1 year,and the recurrence of the two groups was compared.Results The total effective rate of the experimental group was 96.67%,which was higher than 76.67%of the control group(χ^(2)=5.192,P=0.023);After treatment,the levels of IL-16 and IL-18 in the two groups were lower than before treatment,and the experimental group was lower than the control group(P<0.01);After treatment,the levels of Ig G,TRF,and Alb in the two groups were lower than before treatment,and the experimental group was lower than the control group(P<0.05 or P<0.01);After 1 year of follow-up,the recurrence rate of the experimental group was 6.67%lower than 26.67%of the control group(χ^(2)=4.320,P=0.038).Conclusion On the basis of conventional treatment,montelukast sodium in the treatment of children with recurrent allergic purpura can effectively reduce the inflammatory reaction in the children,improve the urine biochemical indicators,reduce the recurrence of the disease,and relieve the pain of the children.The treatment effect is good and it is worthy of promotion.