丹参在肝脏疾病防治中的应用及作用机制研究进展

Research progress in application and mechanism of Danshen in the prevention and treatment of liver disease

丹参为唇形科多年生草本丹参Salvia miltiorrhiza Beg.的干燥根及根茎。临床与药理学研究发现丹参对胆汁淤积性肝损害、免疫性肝损害、肝纤维化、肝癌、药物性肝损伤等多种肝病具有防治作用。本文对丹参在肝脏疾病防治中的应用及作用机制进行了全面综述,以期为丹参相关保肝药物的开发及临床合理用药提供理论指导。

Danshen is the dry roots and rhizomes of perennial herbs of Labiatae plants of Salvia miltiorrhiza Beg.It had been found that Danshen had showed better effects for the prevention and treatment of cholestatic liver damage,immune liver damage,liver fibrosis,liver cancer and drug-induced liver injury in clinical and pharmacological studies.It was reviewed in this article that the applications and mechanism studies of Danshen for the prevention and treatment of liver disease,which will be helpful for the developing of liver-protecting drugs from Danshen and providing guidelines for clinical rational drug use.