盐酸托莫西汀联合执行障碍康复训练治疗小儿多动症效果观察

Effect observation of atomoxetine hydrochloride combined with rehabilitation training for impaired performance in children with ADHD

目的观察盐酸托莫西汀联合执行障碍康复训练治疗小儿多动症(ADHD)的临床疗效。方法纳入2018-01-2019-12在南阳市中心医院接受治疗的92例小儿多动症患儿,观察组和对照组各46例。对照组予以盐酸哌甲酯治疗并接受执行障碍康复训练,观察组予以盐酸托莫西汀治疗并接受执行障碍康复训练,比较2组临床疗效。结果观察组总有效率(91.3%)显著高于对照组(71.7%),差异有统计学意义(χ^(2)=4.168,P=0.032)。治疗后2组多动症Conners儿童行为评定量表评分显著下降,但观察组下降更为突出,患儿认知功能提升显著。观察组不良反应率(17.4%)显著低于对照组(39.1%),差异有统计学意义(χ^(2)=4.466,P<0.05)。结论盐酸托莫西汀联合执行障碍康复训练治疗小儿多动症效果显著,可显著改善患儿的认知能力,且具有良好的安全性。

Objective To observe the clinical study on the treatment of children with attention deficit and hyperactivity disor⁃der(ADHD).Methods Totally 92 children with ADHD who were treated in Nanyang Central Hospital from January 2018 to Decem⁃ber 2019 were collected,and 46 cases in observation group and control group.The control group was treated with methylphenidate hy⁃drochloride and received rehabilitation training for executive dysfunction,while the observation group was treated with Atomoxetine Hydrochloride and received rehabilitation training for executive dysfunction.The efficacy,cognitive function and adverse reactions of the two groups were compared.Results The total effective rate of clinical efficacy in the observation group(91.3%)was significantly higher than that in the control group(71.7%,χ^(2)=4.168,P=0.032).After treatment,the scores of the two groups decreased significantly,but the scores of Conners children's behavior rating scale in the observation group decreased more significantly,and the cognitive function of the children improved significantly.The adverse reaction rate in the observation group(17.4%)was significantly lower than that in the control group(39.1%,χ^(2)=4.466),the difference was statistically significant(P<0.05).Conclusion Tomoxetine hy⁃drochloride has a significant clinical effect in the treatment of ADHD in children,which can reduce the symptoms to some extent,and at the same time has a certain improvement effect in the cognitive ability of children.There are fewer adverse reactions in children during the use of it,and it has a certain safety during the use.