化脓性链球菌磷酸酶转移系统研究进展

Advances in Phosphatase Transfer System of Streptococcus pyogenes

化脓性链球菌(Streptococcus pyogenes)是一种引起人类多种疾病的革兰阳性病原菌,其磷酸烯醇丙酮酸依赖性磷酸转移酶系统(Phosphoenol pyruvate-dependent phosphotransferase pathway, PTS)由系统通透酶(EII)、通用PTS系统蛋白酶I(EI)和含组氨酸蛋白(HPr)组成,受HPr磷酸化状态调节,具有摄取葡萄糖和果糖的功能,PTS组分对SLS、Mga和sagA等毒力因子表达产生影响。主要对PTS系统的组分、调节机制、糖类摄取和对毒力影响等进行综述,为化脓性链球菌PTS系统所影响的调控网络和代谢通路的深入研究提供参考。

Streptococcus pyogenes is a gram-positive pathogen that causes many human diseases. Its phosphoenol pyruvate-dependent phospho-transferase pathway(PTS) is composed of system permease(EII), general PTS, system protease I(EI), and histidine-containing protein(HPr) regulated by the phosphorylation state of HPr, and has functions of ingesting glucose, sugar, and fructose. The PTS component affects the expression of SLS, Mga and sagA and other virulent factors. This article mainly reviews the components of the PTS system, its regulatory mechanism, carbohydrate intake, and its effects on virulence, and provides a basis for in-depth research on regulatory network and metabolic pathways affected by the Streptococcus pyogenes PTS system.