结直肠神经内分泌肿瘤的临床治疗进展

Progress in clinical treatment of colorectal neuroendocrine neoplasms

神经内分泌肿瘤(neuroendocrine neoplasms,NENs)是一类异质性较强的肿瘤,多生长在消化道,尤其是胰腺、直肠等部位。随着内镜等相关检测手段的发展,结直肠神经内分泌肿瘤检出率逐年上升。目前该病的致病机制尚不明确,有研究显示NENs的基因分子变异可能是病因之一。虽然手术治疗仍是局限性结直肠神经内分泌肿瘤的首选治疗方式,但抗肿瘤药物对于晚期以及复发的结直肠NENs病人至关重要。本研究着重介绍结直肠NENs手术及辅助治疗等方面最新研究结果,希望给予医务工作者对该病的诊疗新思路。

Neuroendocrine neoplasms(NENs)are a heterogeneous type of tumor that grows in the digestive tract,especially in thepancreas and rectal.With the development of endoscopy and other detection methods,the detection rate of colorectal neuroendocrinetumor has increased year by year.However,the pathogenesis of the disease is not clear,some studies have shown that the molecularvariation of NENs gene may be one of the causes.Although surgery is still the first choice for localized colorectal NENs,antitumordrugs are important for patients with advanced and recurrent colorectal NENs.This paper focuses on the latest research results ofcolorectal NENs surgery and adjuvant therapy,hoping to give medical workers new ideas on the diagnosis and treatment of this disease.