摘要
RNA修饰在真核生物的基因表达调控中具有重要意义,N^(6)-甲基腺嘌呤(N^(6)-methyladenosine,m^(6)A)是RNA修饰中最常见的一种,可通过影响信使RNA(mRNA)的代谢过程来调控一系列生命活动。本文主要根据近年来在昆虫方面的相关研究成果,归纳了m^(6)A调控酶和识别蛋白的作用机制和m^(6)A动态调控的过程,分析了m^(6)A在mRNA中的分布规律,总结了m^(6)A在昆虫中的典型生物学功能。并从当前研究存在的空白与不足、有待进一步探索的科学问题等方面,对m^(6)A未来在昆虫领域的研究前景进行了展望,以期为后续的研究与探索提供参考。
RNA modifications play vital roles in regulating gene expression of eukaryotes.The most prevalent RNA modification among them is N^(6)-methyladenosine(m^(6)A),which is involved in a series of physiological activities.The mechanism of m^(6)A regulatory enzymes as well as reader proteins,the process of m^(6)A dynamic regulation,and the regular pattern of m^(6)A distribution in mRNAs were introduced,and the typical biological functions of m^(6)A mainly according to the recent progresses made in insects were summarized.Above the review,we preview the research and application prospects of m^(6)A from the aspects of vacancies existing in current study and related phenomenon to be explain,aimed at forming the latest reference for exploration of m^(6)A in insects.
作者
赵书荻
吴小锋
ZHAO Shudi;WU Xiaofeng(Institute of Sericulture and Apiculture,College of Animal Sciences,Zhejiang University,Hangzhou 310058,China;Key Laboratory of Silkworm and Bee Resource Utilization and Innovation of Zhejiang Province,Hangzhou 310058,China)
出处
《浙江大学学报（农业与生命科学版）》
CAS
CSCD
北大核心
2021年第3期295-302,共8页
Journal of Zhejiang University:Agriculture and Life Sciences
基金
国家自然科学基金(31772675,31972619)
浙江省自然科学基金(LZ20C170001)。
