药物致红人综合征文献分析

Analysis of domestic literature of drug-induced red man syndrome

目的探讨药物致红人综合征(RMS)的特点及相关因素,为临床合理用药提供参考。方法检索2010年1月—2020年1月国内医药期刊报道的29篇文章中33例药物致RMS不良反应案例,整理归纳终选文献报道案例的RMS诱导药物、患者年龄、性别、给药途径、药物浓度、滴注速度、不良反应发生时间、临床表现、治疗与转归等。结果国内文献报道能诱导RMS的药物有:替考拉宁、氨曲南、去甲万古霉素、头孢吡肟、万古霉素、血塞通6种;药物致RMS与性别无关,多发于儿童和中老年群体,在输注过程中和输注后均可发生,多表现为皮肤出现红色斑丘疹、皮肤瘙痒、发热等症状,停药并对症处理多可治愈。发生RMS后再次使用诱导药物需进行预处理,否则会再次出现RMS。结论临床应加强对易致RMS药物的合理使用,尽量避免或减少该不良反应的发生。

Objective Discuss the characteristics and related factors of red man syndrome caused by drugs,and provide reference for clinical rational use of drugs.Methods Retrieved 33 cases of drug-induced red man syndrome adverse reactions in 29 articles reported in domestic medical journals from January 2010 to January 2020,sorted out and summarized the RMS-inducing drugs,patient age,gender,and dose of the final selected literature reports.Drug route,drug concentration,infusion speed,time of occurrence of adverse reactions,clinical manifestations,treatment and outcome,etc.Results The domestic literature reports that the drugs that can induce the red man syndrome are:teicoplanin,aztreonam,norvancomycin,cefepime,vancomycin,and xuesaitong;the drugs cause red man syndrome and regardless of gender,it mostly occurs in children and middle-aged and elderly groups.It can occur during and after the infusion.It is mostly manifested as red maculopapular skin,skin itching,fever and other symptoms.Stopping the drug and treating symptomatically can be cured.After the occurrence of the red man syndrome,the re-use of the induction drug requires pretreatment,otherwise the red man syndrome will occur again.Conclusion The rational use of drugs prone to red man syndrome should be strengthened clinically,and the occurrence of such adverse reactions should be avoided or reduced as much as possible.