血清中维生素浓度与结直肠癌患病风险的病例对照研究

Association between serum concentrations of vitamins and their risk of colorectal cancer:A case-control study

目的:分析9种维生素血清浓度与结直肠癌患病风险之间的关系。方法:采用病例对照研究,分别抽取163例结直肠癌患者(试验组)和126名健康查体者(对照组)静脉血2ml,分离血清后,采用电化学发光法维生素检测仪分析脂溶性维生素A、D、E以及水溶性维生素B1、B2、B6、B9(叶酸)、B12和维生素C的血清浓度。比较试验组和对照组维生素血清浓度水平的差异。结果:结直肠癌组和对照组对比,维生素B2、B6、B9(叶酸)、B12和维生素C、D、E的血清浓度水平均显著低于对照组(均P<0.05);多因素logistic回归分析显示在结直肠癌组中维生素B6、B9(叶酸)、B12和维生素E的血清浓度显著低于对照组人群(P<0.05)。结论:血清维生素浓度在结直肠癌患者和健康人群中存在差异,维生素B6、B9(叶酸)、B12和维生素E血清浓度较低可能提示结直肠癌发病风险的升高。

Objective:To explore the association between serum concentrations of nine kinds of vitamins and their risk of colorectal cancer.Methods:In a case-control study,2 ml venous blood was collected from each of163 patients with colorectal cancer(experimental group)and 126 healthy subjects(control group).The serum concentrations of fat-soluble vitamin A,D,E and water-soluble vitamin B1,B2,B6,B9,B12 and vitamin C were analyzed by electrochemiluminescence detector.The differences of vitamin concentrations between the two groups were compared.Results:There were significant differences in serum concentrations of vitamin B2,B6,B9,B12 and vitamin C,D,E between the colorectal cancer group and the control group,and multivariate logistic regression analysis showed that the serum concentrations of vitamin B6,B9,B12 and vitamin E in the colorectal cancer group were significantly lower than those in the control group.Conclusion:There are differences in serum vitamin levels between patients with colorectal cancer and healthy people.Lower serum concentrations of vitamin B6,B9,BB12 and vitamin E may indicate an increased risk of colorectal cancer.