外泌体在鼻咽癌血管生成中的研究进展

Research progress of exosomes in angiogenesis of nasopharyngeal carcinoma

鼻咽癌是发生在鼻咽部黏膜的恶性肿瘤,也是最常见的头颈部肿瘤。通过更精准的放疗,结合同步化疗,鼻咽癌患者的生存率已显著提升,但大多患者在就诊时已是局部晚期或已经发生了远处转移。近年来,随着对鼻咽癌源性的外泌体研究,发现鼻咽癌细胞的外泌体在鼻咽癌的发生、发展中发挥主要作用,尤其是在鼻咽癌新生血管生成、远处转移中扮演重要角色。文章着重探讨鼻咽癌相关外泌体在鼻咽癌的血管生成、远处转移过程中的研究进展。

Nasopharyngeal carcinoma(NPC)is a malignant tumor occurred in the mucous membrane of the nasopharynx and is the most common tumor of the head and neck.Through a more precise radiotherapy,combining synchronous chemotherapy,the survival rate of the patients with NPC has been significantly increased,but most of the patients are locally advanced or have distant metastasis when seeing doctor.In recent years,with the study of nasopharyngeal carcinogenic exosomes,it is found that the exosome of NPC cells play the main role in the occurrence and development of NPC,and play the important role,especially in the new angiogenesis of NPC and distant metastasis.This paper discusses the research progress in NPC related exosome during the angiogenesis and distant metastasis proceess.