老年艾滋病患者中医体质特征与抗逆转录病毒后免疫重建不良相关性研究

The relationship between the TCM constitution characteristics and the poor immune reconstitution after antiretroviral therapy in the elderly patients with AIDS

目的:本研究以接受高效抗逆转录病毒治疗(Highly Active Antireoviral Therapy,HAART)的老年艾滋病患者为研究对象,分析探讨老年艾滋病(Acquired Immune Deficiency Syndrome,AIDS)患者发生免疫重建不良与中医体质的相关性。方法:调查110例老年艾滋病患者,根据中医体质量表评定HAART前与后中医体质类型,并检测各时间点T淋巴细胞CD4^(+),分析中医体质与出现免疫重建不良的相关性。结果:免疫功能低下老年艾滋病患者主要表现为气虚质与阳虚质。免疫重建不良患者中,以气虚质与阳虚质为主,其中阳虚质出现免疫重建不良概率高于其他体质,差异有统计学意义(P<0.05)。结论:阳虚体质与免疫重建不良存在相关性,予以早期辨体质治疗,可能对免疫功能恢复,降低免疫重建不良的发生率有积极作用。

Objective:In this study,the elderly AIDS patients who received antiretroviral therapy were taken as the research objects,and the relationship between the poor immune reconstitution and the TCM constitution characteristics of the elderly patients with AIDS.Methods:110 cases were selected.According to TCM body mass scale,TCM constitution types before and after HAART were evaluated,and CD4^(+)of T lymphocytes at each time point was detected,in order to analyze the correlation between TCM constitution types and the occurrence of poor immune reconstruction.Results:The elderly AIDS patients with poor immune function are mainly characterized by the Qixu type(气虚质)and the Yangxu type(阳虚质).The probability of poor immune reconstitution in patients with the Yang-deficiency constitution type was higher than other TCM constitution types,with a statistically significant difference(P<0.05).Conclusion:There is a correlation between the Yang-deficiency constitution type and the poor immune reconstitution.Early TCM constitution type differentiation plays a positive role in immune function recovery and the reduction of poor immune reconstitution incidence in the elderly patients with AIDS.