FAM60A在细胞功能调控作用中的研究进展

Research Progress of FAM60A in the Regulation of Cellular Function

FAM60A最早被认为是一个细胞周期调控蛋白,通常作为SIN3转录调控蛋白家族成员A/组蛋白去乙酰化酶复合体的一个亚基,在细胞周期调控、形态学改变、增殖、分化和转移,胚胎早期发育及组织器官的发育等过程中发挥重要作用。近年研究表明,FAM60A在肿瘤的发生发展中也起到重要作用,包括人骨肉瘤、食管癌、胃癌、肺癌及肝癌等,为肿瘤的诊断治疗和研究提供了一个新方向。本文总结了近年来的研究成果,探讨了FAM60A在各项细胞功能中的作用。

FAM60A,a cell cycle protein,is a subunit of the SIN3 transcription regulator family member A/histone deacetylase(SIN3-HDAC)complex and plays an important role in cell cycle regulation,cell morphology change,cell proliferation,differentiation and migration,early embryogenesis and so on.Studies in recent years have shown that FAM60A plays a role in the occurrence and development of tumors including human osteosarcoma,esophageal cancer,gastric cancer,lung cancer and liver cancer,providing a new research direction for tumor diagnosis and treatment.Based on the research results in recent years at home and abroad,this paper discussed the effects of FAM60A on cellular functions.