摘要
回顾性总结福建医科大学附属协和医院血液科收治的1例因类风湿关节炎(RA)长期服用甲氨蝶呤(MTX)导致原发口腔黏膜的弥漫大B细胞淋巴瘤(DLBCL)患者的临床病史资料,分析和探讨RA患者服用MTX后诱发特殊部位恶性淋巴瘤的临床特点、诊治及预后情况,旨在提高临床医师与病理科医师对少见其他医源性免疫缺陷相关淋巴增殖性疾病(MTX治疗相关DLBCL)的认识,为MTX治疗相关DLBCL的临床诊疗提供新的借鉴和参考。
A case of primary oral mucosal diffuse large B-cell lymphoma(DLBCL)due to long-term use of methotrexate(MTX)for the treatment of rheumatoid arthritis(RA)was admitted to the Department of Hematology,Fujian Medical University Union Hospital.We analyzed and discussed the clinical features,diagnosis and treatment,and prognosis of specific malignant lymphoma induced by MTX in this RA patient.Our purpose is to improve the awareness and knowledge of other iatrogenic immunodeficiency-associated lymphoproliferative disorders of clinicians and pathologists.This study provides a new reference for the clinical diagnosis and treatment of MTX-associated DLBCL.
作者
刘彦权
胡晓梅
殷悦
张浪辉
付海英
刘庭波
沈建箴
LIU Yanquan;HU Xiaomei;YIN Yue;ZHANG Langhui;FU Haiying;LIU Tingbo;SHEN Jianzhen(First Clinical Medical College,First Affiliated Hospital of Gannan Medical University,Ganzhou,Jiangxi 341000,China;Department of Hematology,Fujian Medical University Union Hospital,Fuzhou 350001,China;Department of Pathology,Fujian Medical University Union Hospital,Fuzhou 350001,China;Department of Cell Morphology,Fujian Medical University Union Hospital,Fuzhou 350001,China)
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2021年第3期488-493,共6页
Acta Academiae Medicinae Sinicae
基金
国家自然科学基金(81300428)
福建省血液医学中心建设项目(闽卫医政[2017]171号)
国家及福建省临床重点专科建设项目(闽卫医函[2011]1018号、闽卫科教[2012]149号)。
关键词
其他医源性免疫缺陷相关淋巴增殖性疾病
免疫抑制剂
甲氨蝶呤
甲氨蝶呤相关淋巴组织增殖性疾病
淋巴瘤
结外淋巴瘤
other iatrogenic immunodeficiency-associated lymphoproliferative disorders
immunosuppressive agents
methotrexate
methotrexate-associated lymphoproliferative disorders
lymphoma
extranodal lymphoma
