免疫抑制性细胞在免疫性血小板减少症中的作用

The Role of Immunosuppressive Cells in Immune Thrombocytopenia

免疫性血小板减少症(ITP)是一种自身免疫性疾病,其特征是循环血小板数量显著减少及常伴有出血。虽然ITP的发病机制尚未完全阐明,但目前普遍认为T、B淋巴细胞功能紊乱参与了ITP的发病机制。ITP临床表现复杂,治疗过程存在异质性,其原因在于病理机制的复杂性。因此,更好地了解ITP的不同发病机制对于探索更有效的治疗是必要的。最近,越来越多的研究揭示免疫抑制性细胞对ITP的发病机制存在重要影响。为此,本文主要综述不同免疫抑制细胞在ITP中的作用,以期为临床探索该病的治疗方法提供帮助。

Immune thrombocytopenia(ITP)is an autoimmune disease characterized by a significant reduction in the number of circulating platelets and often accompanied by bleeding.Although the pathogenesis of ITP has not been fully elucidated,it is generally believed that the dysfunction of T and B lymphocytes is involved in the pathogenesis of ITP.The clinical manifestations of ITP are complex and the treatment process is heterogeneous.The reason lies in the complexity of the pathological mechanism.Therefore,a better understanding of the different pathogenesis of ITP is necessary to explore more effective treatments.Recently,more and more studies have revealed that immunosuppressive cells have an important influence on the pathogenesis of ITP.To this end,this article mainly reviews the role of different immunosuppressive cells in ITP,in order to provide help for clinical exploration of the treatment of the disease.