克隆性造血与血细胞减少的研究进展

Progress of clonal hematopoiesis and cytopenia

克隆性造血是有特定遗传学和分子生物学标志特征的造血干细胞分化成为各系成熟血细胞的一种特殊的造血模式,是多种血液系统疾病的发病基础。深入了解其病因、机制以及特征,有利于认识其在不同人群或疾病中的价值。文章就克隆性造血的最新进展及其相关克隆性疾病进行综述。

Clonal hematopoiesis is a special mode of hematopoiesis in which hematopoietic stem cells with specific genetic and molecular biological characteristics differentiate into mature blood cells.It is the basis of a variety of hematological diseases.In depth study of its etiology,mechanism and characteristics are conducive to our understanding of the value of clonal hematopoiesis in different populations or diseases.This article reviews the latest progress in clonal hematopoiesis and its related clonal diseases.