间歇性θ脉冲刺激对2型糖尿病合并轻度认知功能障碍患者脑电图频率谱与频率比的影响

Effect of intermittentθpulse stimulation on frequency spectrum and frequency ratio of EEG in patients with type 2 diabetes mellitus and mild cognitive impairment

目的探讨单次间歇性θ脉冲刺激对2型糖尿病合并轻度认知功能障碍患者静息脑电图频率谱与频率比的影响。方法2020年7—11月在深圳宝安医院下属社区卫生服务中心招募40例2型糖尿病合并轻度认知功能障碍患者,按随机数字表法分为真刺激组(20例)和假刺激组(20例)。每位患者首先接受5 min静息脑电图采集,再用单脉冲测量静息运动阈值,以80%强度进行一次间歇性θ脉冲刺激,刺激后立即再次进行5 min静息脑电图采集。结果间歇性θ脉冲刺激干预后,假刺激组干预前后各电极通道各频段的绝对功率差异无统计学意义。假刺激组和真刺激组刺激后各电极通道各频段的绝对功率差异无统计学意义。但真刺激组干预后与刺激前相比,T7和CP6通道的β频段绝对功率显著增高,分别为(45.83±8.28)μV~2、(39.84±11.10)μV~2,差异有统计学意义(P=0.042、P=0.040)。与刺激前相比,真刺激组刺激后T7通道的(δ+θ)/(α+β)频率比显著降低,差异有统计学意义(P=0.041)。且经多因素回归分析发现,受试者的性别、年龄、体重指数和病程与绝对功率的变化差异无统计学意义(均P>0.05)。结论单次间歇性θ脉冲刺激干预后,可提高2型糖尿病合并轻度认知功能障碍患者颞区T7和CP6通道β频段的绝对功率,并降低T7通道的频率比。iTBS通过影响2型糖尿病合并轻度认知功能障碍患者的认知加工过程,从而改善认知功能。

Objective To investigate the effect of single intermittentθpulse stimulation on the frequency spectrum and frequency ratio of resting EEG in patients with type 2 diabetes mellitus and mild cognitive impairment.Methods From July to November 2020,40 patients with type 2 diabetes mellitus complicated with mild cognitive impairment were recruited in the community health service center affiliated to Shenzhen Bao’an Hospital.They were randomly divided into true stimulation group(n=20)and sham stimulation group(n=20).Each patient received a 5 min resting EEG collection first,with a single pulse measurement resting movement threshold,an intermittentθpulse was stimulated at 80%intensity,and EEG was collected at rest for 5 min immediately after stimulation.Results After the intervention of intermittentθpulse stimulation,there was no significant difference in the absolute power of each electrode channel and each frequency band before and after the intervention of sham stimulation group.There was no significant difference in the absolute power of each frequency band of the electrode channel between the sham stimulus group and the true stimulus group.However,in the true stimulation group,the absoluteβ-band power of T7 and CP6 channels increased significantly after intervention compared with before stimulation,respectively(45.83±8.28)μV~2,(39.84±11.10)μV~2,the difference was statistically significant(P=0.042,P=0.040).Compared with before stimulation,the(δ+θ)/(α+β)frequency ratio of T7 channel in the true stimulation group decreased significantly after stimulation,the difference was statistically significant(P=0.041).Multivariate regression analysis showed that gender,age,body mass index,disease course and absolute power of the subjects had no statistical significance(all P>0.05).Conclusion After a single intervention of intermittentθpulse stimulation,the absolute power ofβ-band of T7 and CP6 channels in the temporal region of type 2 diabetes mellitus patients with mild cognitive impairment was increased,and reduce the frequency ratio of the T7 channel.iTBS improves cognitive function by affecting cognitive processing in patients with type 2 diabetes with mild cognitive impairment.