冠心病患者冠脉狭窄程度的危险因素分析

The analysis of risk factors of coronary stenosis in patients with coronary heart disease

目的分析冠心病患者冠脉狭窄程度的危险因素。方法按照入院时间和入院人群类别将2018年2月至2019年3月于我院接受治疗的98例冠心病患者为实验组,另选取同期于我院接受体格检查的50例健康者为对照组,对比两组对象ApoE、Hcy及低密度脂蛋白(LDL)水平,不同冠脉病变程度患者ApoE、Hcy及LDL水平,以及对冠心病患者不同冠脉狭窄程度进行单因素分析。结果(1)实验组ApoE、Hcy及LDL水平均明显高于对照组,差异有统计学意义(P<0.05);(2)冠心病患者中ApoE及LDL水平为重度狭窄组>中度狭窄组>轻度狭窄组>无冠脉狭窄组,差异有统计学意义(P<0.05);(3)高血压、糖尿病、吸烟、LDL为冠状动脉狭窄程度的单因素影响因素(P<0.05),高血压(OR=1.021,95%CI:1.041~1.156)、糖尿病(OR=3.206,95%CI:1.465~7.526)、吸烟(OR=3.625,95%CI:1.563~8.023)、LDL(OR=6.384,95%CI:6.877~21.470)是影响冠心病患者冠脉狭窄程度危险因素(P<0.05)。结论ApoE、Hcy、LDL、高血压、糖尿病、吸烟等均为冠心病患者冠脉狭窄程度的危险因素。

Objective To analyze the risk factors of the degree of coronary stenosis in patients with coronary heart disease(CHD).Methods A total of 98 patients with CHD treated in our hospital from February 2018 to March 2019 were selected as the experimental group according to admission time and admission population category.50 healthy individuals who underwent physical examination in our hospital during the same period were selected as the control group.The levels of ApoE,Hcy and low density lipoprotein(LDL)of the two groups were compared,and the levels of ApoE,Hcy and LDL in patients with different degrees of coronary artery lesions were compared.Univariate analysis was carried out on patients with different degrees of coronary artery stenosis.Results(1)The levels of ApoE,Hcy and LDL in the experimental group were significantly higher than those in the control group,with significant difference(P<0.05).(2)The levels of ApoE,Hcy,and LDL were the highest in the moderate and severe stenosis group,followed by moderate stenosis group,mild stenosis group and non-coronary stenosis group,with statistically significant differences among these groups(P<0.05).(3)Hypertension,diabetes mellitus,smoking and LDL were the single factor influencing the degree of coronary artery stenosis(P<0.05).Hypertension(OR=1.021,95%CI:1.041-1.156),diabetes mellitus(OR=3.206,95%CI:1.465-7.526),smoking(OR=3.625,95%CI:1.563-8.023)and LDL(OR=6.384,95%CI:6.877-21.470)were the risk factors of the degree of coronary artery stenosis in patients with CHD(P<0.05).Conclusion ApoE,Hcy,LDL,hypertension,diabetes and smoking were all risk factors for the degree of coronary artery stenosis in patients with CHD.