厦门地区49652例女性高危型HPV感染情况及年龄分布

High-risk HPV infection status and age distribution among 49652 women in Xiamen

目的分析福建厦门地区女性高危型人乳头瘤病毒(High-risk human papillomavirus,HR-HPV)感染率和年龄分布情况,为预防高危型HPV感染和降低宫颈癌的发生率提供依据。方法采用杂交捕获二代法(Hybrid capture 2,HC2)技术,对2015年1月至2017年7月在厦门大学附属第一医院进行机会性筛查的49652例标本进行13种高危型HPV检测(HPV16、18、31、33、35、39、45、51、52、56、58、59、68),分析高危型HPV感染率及年龄分布情况。结果49652例接受机会性高危型HPV筛查病例中,高危型HPV阳性8965例,总阳性率18.06%。高危型HPV感染的高峰年龄在30岁之前及50~70岁,<30岁人群阳性率20.24%(1821/8997),30~49岁人群阳性率16.57%(5475/33047),50~70岁人群阳性率22.13%(1614/7294),>70岁人群阳性率17.52%(55/314)。各年龄组间高危型HPV感染阳性率差异有统计学意义(P<0.05)。高危型HPV阳性的标本中7148例做了16/18分型,其中HPV16阳性536例,占7.50%,HPV18阳性279例,占3.90%。结论福建厦门地区女性高危型HPV感染有年龄分布差异,各年龄段均要加强HPV筛查检测,选择性合理接种HPV疫苗,降低本地区宫颈癌的发病率。

Objective To analyze the infection rate and age distribution of high-risk human papillomavirus(HR-HPV)among women in Xiamen,Fujian,to provide evidence for preventing high-risk HPV infection and reducing the incidence of cervical cancer.Methods Used hybrid capture 2(HC2)technology,49652 specimens receiving opportunistic screening in The First Affiliated Hospital of Xiamen University from January 2015 to July 2017 were tested for 13 high-risk HPV types(HPV-16,18,31,33,35,39,45,51,52,56,58,59 and 68).The high-risk HPV infection rate and age distribution were analyzed.Results Among 49652 specimens receiving opportunistic screening for high-risk HPV infection,8965 were positive for high-risk HPV infection,with a total positive rate of 18.06%.The peak ages of high-risk HPV infection were<30 years old and between 50-70 years old.The positive rate of women was 20.24%(1821/8997)for<30 years old,16.57%(5475/33047)for 30-49 years old,22.13%(1614/7294)for 50-70 years old,and 17.52%(55/314)for>70 years old.There were statistically significant differences in the positive rates of high-risk HPV infection among the age groups(P<0.05).Among positive high-risk HPV infection specimens,7,148 were classified as HPV-16/18,of which 536 were HPV-16 positive,accounting for 7.50%,and 279 were HPV-18 positive,accounted for 3.90%.Conclusion There are differences in the age distribution of high-risk HPV infection among women in Xiamen,Fujian.HPV screening and testing should be strengthened in all age groups,and HPV vaccines should be selectively and reasonably vaccinated to reduce the incidence of cervical cancer in the region.