左氧氟沙星联合抗结核药物治疗肺结核合并肺部感染的效果及并发症发生率观察

Observation on the effect and complication rate of levofloxacin combined with anti-tuberculosis drugs in the treatment of pulmonary tuberculosis with pulmonary infection

目的探讨左氧氟沙星联合抗结核药物治疗肺结核合并肺部感染患者的疗效及对并发症发生率的影响。方法选取我院结核科2018年1月至2019年7月收诊的肺结核合并肺部感染患者149例为对象,以电脑随机法分组,对照组(n=75)应用抗结核药物和青霉素类、头孢菌素类抗感染治疗,试验组(n=74)应用左氧氟沙星和抗结核药物治疗,比较两组的治疗总有效率、痰菌转阴率、并发症发生率等。结果试验组患者的治疗总有效率为95.95%,高于对照组的85.33%,差异有统计学意义(P<0.05);治疗14 d后的痰菌转阴率,试验组为94.59%,对照组为81.33%,差异有统计学意义(P<0.05);试验组的痰菌转阴时间短于对照组(P<0.001);两组患者的治疗疗程比较,差异无统计学意义(P>0.05);试验组的住院时间短于对照组(P<0.001);观察组患者的并发症发生率(9.46%)与对照组(12.00%)比较,差异无统计学意义(P>0.05);随访观察1年,试验组的肺部感染复发率为5.41%,低于对照组的16.00%(P<0.05)。结论左氧氟沙星联合常规抗结核药物治疗肺结核合并肺部感染疗效满意,有助于缩短住院时间,促进患者早日康复,且并发症少,复发率低,值得推广。

Objective To explore the effect of levofloxacin combined with anti-tuberculosis drugs in the treatment of pulmonary tuberculosis patients with pulmonary infection and its influence on the incidence of complications.Methods A total of 149 patients with pulmonary tuberculosis and pulmonary infection admitted in our hospital from January 2018 to July 2019 were selected as subjects,and were grouped by the computer random method.Seventy-five patients in the control group were treated with anti-tuberculosis drugs,penicillins,and cephalosporins.Seventy-four patients in the experimental group were treated with levofloxacin and anti-tuberculosis drugs.The total effective rate of treatment,sputum negative conversion rate,the complication rate of the two groups were compared.Results The total effective rate of treatment in the experimental group was 95.95%,which was higher than that(85.33%)of the control group,the difference was statistically significant(P<0.05).After 14 days of treatment,the negative rate of sputum bacteria in the experimental group was 94.59%,which was shorter than that(81.33%)in the control group,the difference was statistically significant(P<0.05).There was no statistically significant difference in the course of treatment between the two groups,the difference was not statistically significant(P>0.05).The hospital stay in the experimental group was shorter than that in the control group(P<0.001).There was no statistically significant difference between the complication rate of 9.46%in the observation group and the complication rate of 12.00%in the control group(P>0.05).After a 1-year follow-up,the recurrence rate of lung infection in the experimental group was 5.41%,lower than that(16.00%)of the control group(P<0.05).Conclusion The levofloxacin combined with conventional anti-tuberculosis drugs in the treatment of pulmonary tuberculosis complicated with pulmonary infection has a satisfactory effect,which can help shorten the length of hospitalization,promote the patient′s early recovery,and has fewer complications and low recurrence rate.It is worthy of promotion.