lncRNA调控间充质干细胞向成骨细胞分化的研究进展

Research progress of lncRNA regulating the differentiation of mesenchymal stem cells into osteoblasts

间充质干细胞(MSCs)是一种多能性基质细胞,已被证实具有向骨、软骨、脂肪、肌肉、神经、心肌和内皮等多种组织细胞分化的能力,且其在骨再生修复中发挥重要作用。长链非编码RNA(lncRNA)通过多种途径影响MSCs向成骨细胞分化的过程,同时在骨代谢平衡的过程中有着重要的调控作用。本文综述了lncRNA调控MSCs成骨分化的最新研究进展,为进一步研究lncRNA调节MSCs成骨分化及骨形成的机制提供新思路。

Mesenchymal stem cells(MSCs)are pluripotent stromal cells,which have been proved to have abilities to differentiate into osteoblasts and adipocytes,and play an important role in bone regeneration and repair.Recent studies showed that long non-coding RNA(lncRNA)was differentially expressed in the process of osteogenic differentiation of MSCs,and affected the process of osteogenic differentiation of MSCs in many ways.It also played an important role in regulating the balance of bone metabolism.This paper reviewed the latest research progress of lncRNA in the regulation of osteogenic differentiation of MSCs and provided a new idea for further research on the mechanisms of lncRNA regulating the osteogenic differentiation and bone formation of MSCs.