停经前后类风湿性关节炎患者临床特点及中医辨证分型分析

Clinical Characteristics and TCM Syndrome Differentiation Analysis of 106 Patients with Rheumatoid Arthritis before and after Menopause

目的:探讨停经前后RA患者临床特点、中医辨证分型的不同,为后续对于女性RA患者的研究提供思路。方法:将患有RA且疾病正处于活动期的女性患者共106例分为停经前后2组。统计分析2组患者的临床特点(主要受累关节、BMI、DAS28-ESR积分等)、实验室指标和中医辨证分型分布规律。结果:停经组患者在膝、踝关节受累例数、BMI、ESR、CRP均值等方面显著高于未停经组(P<0.05);停经组以湿热痹阻型最多(25.9%),未停经组以风湿痹阻型最多(38.5%)。结论:停经组RA患者的膝、踝关节受累较未停经组严重,其原因可能与BMI变化及ESR、CRP等免疫炎性指标密切相关。

Objective:To explore the differences in the clinical characteristics and TCM syndrome differentiation of RA patients before and after menopause,and to provide ideas for the follow-up research on female RA patients.Methods:A total of 106 female patients with RA and whose disease was at the active stage were divided into two groups before and after menopause.The clinical characteristics of the two groups of patients(mainly affected joints,BMI,DAS28-ESR score,etc.),laboratory indicators and the distribution of TCM syndromes were statistically analyzed.Results:The number of cases of knee and ankle involvement,BMI,ESR,and CRP mean values of the menopausal group were significantly higher than those of the non-menopausal group(P<0.05);the menopausal group had the most damp-heat block type(25.9%),and the non-menopausal group had the most wind-damp block type(38.5%).Conclusion:The knee and ankle joint involvement of RA patients in the menopausal group is more serious than that in the non-menopausal group.The reason may be closely related to the BMI,ESR,CRP and other immuno-inflammatory indicators.