鳞状细胞癌抗原、人绒毛膜促性腺激素及肿瘤特异性生长因子在子宫内膜癌中的表达及临床意义分析

Expression and clinical significance of squamous cell carcinoma antigen, human chorionic gonadotropin and tumor specific growth factor in endometrial cancer

目的探讨子宫内膜癌患者鳞状细胞癌抗原(SCC-Ag)、人绒毛膜促性腺激素(HCG)及肿瘤特异性生长因子(TSGF)水平,并分析其意义。方法选取子宫内膜癌患者与子宫良性病变患者各148例分别作为子宫内膜癌组与良性病变组,并取148例健康体检者作为对照组,比较3组研究对象SCC-Ag、HCG、TSGF水平,并分析其与子宫内膜癌临床特征及预后的关系。结果子宫内膜癌组患者SCC-Ag、HCG及TSGF水平均高于良性病变组与对照组,良性病变组患者HCG、TSGF水平均高于对照组,差异均有统计学意义(P﹤0.05)。TNM分期为Ⅲ-Ⅳ期、有淋巴结转移、浸润程度为T3-4的子宫内膜癌患者SCC-Ag、HCG、TSGF高表达率分别高于TNM分期为Ⅰ-Ⅱ期、无淋巴结转移、浸润程度为T1-2的患者,肿瘤直径﹥5.0 cm的子宫内膜癌患者SCC-Ag高表达率高于肿瘤直径≤5.0 cm患者,分化程度为中低分化的子宫内膜癌患者TSGF高表达率高于分化程度为高分化的患者,差异均有统计学意义(P﹤0.05)。SCC-Ag、HCG、TSGF高表达患者总生存率均低于SCC-Ag、HCG、TSGF低表达患者,差异均有统计学意义(P﹤0.05)。结论SCC-Ag、HCG、TSGF在子宫内膜癌患者中表达升高,且与肿瘤直径、TNM分期、分化程度、淋巴结转移以及浸润程度有关,能够对预后评估起到一定指导作用。

Objective To explore the levels and significance of squamous cell carcinoma antigen(SCC-Ag),human chorionic gonadotropin(HCG)and tumor specific growth factor(TSGF)in patients with endometrial cancer.Method A total of 148 patients with endometrial cancer and 148 patients with benign endometrial lesions were enrolled as endometrial cancer group and benign lesion group,respectively,with additional 148 healthy subjects as control group.The levels of SCC-Ag,HCG and TSGF were compared among the three groups,their relationship with clinical characteristics and prognosis of endometrial cancer were analyzed.Result The levels of SCC-Ag,HCG and TSGF in endometrial cancer group were significantly higher than those in benign lesion group and control group(P<0.05).The levels of HCG and TSGF in benign lesion group were significantly higher than those in control group(P<0.05).The high expression rates of SCC-Ag,HCG and TSGF in patients with TNM stageⅢ-Ⅳ,lymph node metastasis and infiltration degree of T3-4 were significantly higher than those with TNM stageⅠ-Ⅱ,without lymph node metastasis and infiltration degree of T1-2;the high expression rate of SCC-Ag in patients with tumor diameters>5.0 cm was significantly higher than that with tumor diameters≤5.0 cm;the high expression rate of TSGF in patients with low to moderate differentiation was significantly higher than that with high differentiation(P<0.05).The overall survival rate of patients with high expression of SCC-Ag,HCG and TSGF were significantly lower than those with low expression(P<0.05).Conclusion The expression of SCCAg,HCG and TSGF is increased in patients with endometrial cancer,which are related to tumor diameter,TNM staging,differentiation degree,lymph node metastasis and infiltration degree,and can provide guidance in prognosis evaluation.