西安市219例海洛因依赖肺结核感染者合并HCV的感染情况及影响因素

HCV infection in 219 heroin addicts with pulmonary tuberculosis in Xi’an

目的了解海洛因依赖肺结核感染者合并丙型肝炎病毒(hepatitis C virus,HCV)感染状况及影响因素,为防治措施的制定提供科学依据。方法收集西安市第八医院219例海洛因依赖肺结核感染者的人口社会学特征、吸毒史并进行血清学检测,通过χ2检验及多因素Logistic回归方法分析HCV感染的危险因素。结果海洛因依赖人群肺结核合并HCV感染率为71.2%,高于合并HBV(10.9%)、HIV(5.9%)感染率,其中海洛因静脉注射者肺结核合并HCV感染率为92.9%。感染的危险因素为静脉注射(OR=18.632,95%CI:8.146~41.284)及海洛因依赖时长(OR=1.428,95%CI:1.086~1.876)。结论海洛因依赖肺结核感染者合并HCV感染率高,静脉注射、海洛因依赖时间是独立的危险因素,应加强相应人群的管理体系,以防止合并感染蔓延。

Objective To explore the incidence rate and characteristics of hepatitis-C virus(HCV)infection in heroin addicts with pulmonary tuberculosis(TB)in Xi’an so as to provide a basis for pulmonary TB and HCV prevention and control measures.Methods We carried out behavior investigation and serological detection of 219 heroin addicts with pulmonary TB infection in Xi’an Eighth Hospital.We analyzed HCV infection risk factors by Chi-square test and multi-factor Logistic regression method.Results The prevalence of HCV infection in heroin addicts with pulmonary TB was 71.2%and 92.9%in injected drug users(IDUs).The HCV infection rate was higher than the infection rate of HBV(10.9%)and HIV(5.9%)in heroin addicts with pulmonary TB.The major infection risk factors were intravenous injection(OR=18.632,95%CI:8.146-41.284)and longer duration of drug use(OR=1.428,95%CI:1.086-1.876).Conclusion The study found high HCV infection rate in heroin addicts with pulmonary TB and that the independent risk factors are the drug injection and duration of drug use.In order to prevent further spread of HCV in heroin addicts with pulmonary TB,we should establish and perfect the management system of HCV infection.