白细胞介素-6与慢性乙型病毒性肝炎进展的关系

The relationship between interleukin-6 and progression of chronic hepatitis B

白细胞介素-6(IL-6)是一种具有多效生物活性的炎性细胞因子,参与体内多种炎症反应介导的免疫损伤,在病毒感染性疾病及其进展中影响深远。乙型肝炎病毒(HBV)感染宿主后可引起一系列炎性免疫反应,导致乙型病毒性肝炎、肝硬化甚至肝细胞癌等多种疾病的发生。大量研究表明IL-6与乙型病毒性肝炎发生及进展密切相关。本文旨在对IL-6与HBV感染、病毒复制及慢性乙型病毒性肝炎、肝硬化及肝癌进展的相关性作一综述,并评估IL-6基因多态性在乙型病毒性肝炎进展中的作用,以期为慢性乙型病毒性肝炎肝硬化靶向治疗提供帮助。

Interleukin-6(IL-6)is an inflammatory cytokine with pleiotropic activity.IL-6 participates in the immune damage mediated by various inflammatory reactions in the body and plays an important role in virus infectious diseases and their progression.Hepatitis B virus(HBV)can cause a series of inflammatory immune responses after infecting the host,leading to the occurrence of various diseases such as hepatitis B,liver cirrhosis and even hepatocellular carcinoma.A large number of studies have shown that IL-6 is closely related to the occurrence and progression of hepatitis B.This article aims to review the correlation of IL-6 with HBV infection and replication,as well as its relevance to the progression of chronic hepatitis B,liver cirrhosis and hepatocellular carcinoma,and to evaluate the influence of its genetic polymorphism on the progression of hepatitis B.It hopes to provide references for the prevention and treatment of chronic hepatitis B and the related liver cirrhosis.