二氧化钼-石墨烯修饰电极对多巴胺、尿酸检测方法研究

Detection of Dopamine and Uric Acid by Molybdenum Dioxide-Graphene Modified Electrode

将MoO_(2)/RGO纳米复合材料滴涂于玻碳电极表面以构筑电化学传感器并将其用于多巴胺和尿酸的测定中,结果表明:MoO_(2)和石墨烯的协同作用能够促进多巴胺和尿酸的电化学反应,并且二者的氧化峰电位差大于120 mV,该传感器检测DA的线性范围为2~220μmol/L,UA的线性范围为9~300μmol/L,检出限分别为0.68μmol/L和1.06μmol/L(S/N=3)。制备的MoO_(2)/RGO/GCE成功用于人体尿液的检测。设计的传感器具有较宽的线性范围,较低的检测限,优异的重现性、稳定性、选择性,可以用于实际样品中DA和UA的检测。

MoO_(2)/RGO nanocomposite was drip-coated on the surface of glassy carbon electrode(GCE)to construct an electrochemical sensor and used it for the determination of DA and UA.The results showed that the synergistic effect of MoO_(2) and RGO has a good catalytic effect on DA and UA,at the same time,the oxidation peak potential difference(ΔEpa)of the two was more than 120 m V.The linear range of DA and UA on the modified electrode was 2~220μmol/L and 9~300μmol/L,respectively.The detection limits(S/N=3)of DA and UA were 0.68μmol/L,1.06μmol/L.More importantly,the prepared MoO_(2)/RGO/GCE was successfully used for the detection DA and UA in human urine.In a word,the designed sensor in this study showed wider linear range,lower detection limits,excellent reproducibility,stability and selectivity,and it can also be used to detect DA and UA in real samples.