甲巯咪唑致粒细胞缺乏伴发热1例的药学监护

Pharmaceutical Care of a Case of Methimazole Induced Agranulocytosis with Fever

目的:探讨临床药师在甲状腺功能亢进(甲亢)患者药物治疗中的作用。方法:通过对1例使用甲巯咪唑致粒细胞缺乏的甲亢患者进行药学监护,临床药师与临床医生密切配合,根据患者的基本情况预估甲巯咪唑致粒细胞缺乏症患者的愈后终点,合理选择并调整抗菌药物的治疗方案以及对患者进行用药宣教。结果:患者取得良好的治疗效果,病情好转并稳定后顺利完成放射性^(131)I治疗,平安出院。结论:甲巯咪唑引起的粒细胞缺乏病情重、病程长,甚至可危及患者的生命,在发现粒细胞缺乏时,选择合理的治疗方案,可明显改善患者预后,缩短住院时间。

Objective:To investigate the role of clinical pharmacists in drug treatment through the pharmaceutical monitoring of a case of hyperthyroidism with agranulocytosis caused by methimazole.Methods:Clinical pharmacists and clinicians work closely together to estimate the outcome of methimazole-induced agranulocytosis patients based on the basic conditions of the patients,rationally select and adjust the antibacterial drug treatment plan,and educate the patients on medication.Results:The patient achieved good therapeutic effect,and his condition improved and stabilized after he successfully completed the radioactive ^(131)I treatment of hyperthyroidism and was discharged from the hospital.Conclusion:Agranulocytosis caused by methimazole is serious and has a long course,and can even endanger the life of the patient.When agranulocytosis is found,choosing a reasonable treatment plan can significantly improve the patient's prognosis and shorten the hospital time.