益气清热降浊法对慢性肾脏病3~4期患者氧化应激指标的影响

Effect of Benefiting qi,Clearing Away Heat and Reducing Turbidity Method on Oxidative Stress Indexes of Patients with Chronic Kidney Disease in 3~4 Stages

目的探究益气清热降浊对慢性肾脏病3~4期患者氧化应激指标的影响。方法选取吉林市龙潭区铁东医院2018年2月—2019年10月收治的83例慢性肾脏病3~4期患者开展研究,采用随机化分组法分为治疗组(42例)和对照组(41例),对照组采用氯沙坦钾治疗,治疗组采用益气清热降浊中药治疗,治疗后比较2组中医证候积分、氧化应激指标。结果干预后,治疗组患者中医证候积分低于对照组,超氧化物歧化酶(Superoxide dismutase,SOD)、谷胱甘肽过氧化物酶(Glutathione peroxidase,GSH-PX)均高于对照组,差异均具有统计学意义(P<0.05)。结论在慢性肾脏病3~4期患者中应用益气清热降浊治疗,能够改善临床症状,稳定氧化应激指标水平。

Objective To explore the effect of benefiting qi,clearing away heat and reducing turbidity on the oxidative stress index of patients with chronic kidney disease in 3~4 stages.Methods From February 2018 to October 2019,83 patients with chronic kidney disease of stage 3~4 were selected for the study.They were randomly divide into control group(n=41,losartan potassium)and treatment group(n=42,Chinese medicine for nourishing qi,clearing heat and reducing turbidity).The traditional Chinese medicine(TCM)syndrome score and oxidative stress index of the two groups was compared.Results After intervention,the TCM syndrome score of treatment group was lower than that of control group,the superoxide dismutase(SOD)and glutathione peroxidase(GSH PX)of treatment group were higher than that of control group,and there was significant difference between the two groups(P<0.05).Conclusion Benefiting qi,clearing away heat and reducing turbidity in the treatment of stage 3~4 chronic kidney disease can improve clinical symptoms and stabilize oxidative stress indicators.