周氏化湿解表汤对湿热证患者病毒性上呼吸道感染的干预效果

Effect of Zhoushi Huashi Jiebiao Decoction for viral upper respiratory tract infection patients differentiated as damp and heat syndrome

目的观察周氏化湿解表汤治疗病毒性上呼吸道感染湿热证患者的效果。方法将70例患者分为中药组(n=35)和西药照组(n=35),分别给予周氏化湿解表汤治疗和奥司他韦胶囊治疗。记录治疗后体温恢复正常时间,观察治疗前后咽痛、纳差及全身不适等症状的改善情况。治疗前后分别采集静脉血并检测CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)和NK细胞水平。结果2组退热时间、中医治疗总有效率比较,差异有统计学意义(P<0.05或P<0.01)。治疗后,中药组CD8^(+)、CD4^(+)/CD8^(+)、CD4^(+)、CD3^(+)4项淋巴细胞亚群较治疗前上升,差异有统计学意义(P<0.05),NK呈现下降趋势,但差异无统计学意义(P>0.05);治疗后,西药组CD4^(+)/CD8^(+)、CD8^(+)、CD4^(+)、CD3^(+)淋巴细胞亚群及NK水平与治疗前比较,差异无统计学意义(P>0.05)。治疗后,中药组高热、全身不适、咽痛、纳差消失率与西药组比较,差异有统计学意义(P<0.01)。结论周氏化湿解表汤治疗湿热证的急性上呼吸道病毒感染疾病能够调节体内免疫机制水平,临床疗效优于单纯西药治疗。

Objective To observe effect of Zhoushi Huashi Jiebiao Decoction for viral upper respiratory tract infection patients differentiated as damp and heat syndrome.Methods A total of 70 patients were randomly divided into traditional Chinese medicine(TCM)group(n=35)and western medicine group(n=35),given Zhoushi Huashi Jiebiao Decoction and oseltamivir capsules,respectively.The disappearance time of fever after treatment was recorded,and the improvement of symptoms such as sore throat,poor appetite and body discomfort before and after treatment was observed.Venous blood was collected before and after treatment,and CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+)and NK cell levels were detected.Results There were statistical significant differences in disappearance time of fever and the total effective rate of TCM syndromes between the two groups(P<0.05 or P<0.01).After treatment,CD8^(+),CD4^(+)/CD8^(+),CD4^(+)and CD3^(+)lymphocyte subsets in the TCM group increased significantly compared with before treatment(P<0.05),while NK level showed a decrease,but no significant difference was found(P>0.05).After treatment,CD4^(+)/CD8^(+),CD8^(+),CD4^(+),CD3^(+)lymphocyte subsets and NK level in the western medicine group showed no significant differences compared with before treatment(P>0.05).After treatment,the disappearance rates of high fever,body discomfort,sore throat and poor appetite in the TCM group showed significant differences compared to the western medicine group(P<0.01).Conclusion Zhoushi Huashi Jiebiao Decoction in treating acute viral infection of upper respiratory tract of damp heat syndrome can regulate the level of immune mechanism in vivo,and its clinical efficacy is better than that of western medicine alone.