翼状螺旋转录因子3及白细胞介素-10联合临床特征预测男性肛管内尖锐湿疣复发的价值

Value of forkhead box protein 3 and interleukin-10 combined with clinical features in predicting recurrence of male patients with intra-anal condyloma acuminatum

目的分析翼状螺旋转录因子3(Foxp3)、白细胞介素-10(IL-10)联合临床特征预测男性肛管内尖锐湿疣复发的价值。方法回顾性分析160例肛管内尖锐湿疣男性患者临床资料,按照复发情况分为复发组(n=98)和未复发组(n=62),比较2组临床特征及Foxp3、IL-10水平。采用受试者工作特征(ROC)曲线分析Foxp3、IL-10最佳截断值,采用Logistic回归分析模型分析尖锐湿疣复发的危险因素。结果复发组单纯手术切除、熬夜、嗜酒、人类乳头瘤病毒-脱氧核糖核酸(HPV-DNA)分型为高危及混合、合并其他性病、疣体直径≥0.5 cm、药物中断患者比率及Foxp3、IL-10水平高于未复发组,差异有统计学意义(P<0.05)。ROC曲线分析显示,Foxp3、IL-10的曲线下面积分别为0.881、0.910。Logistic回归分析显示,Foxp3≥0.195%、IL-10≥394.210 ng/L、单纯手术切除、熬夜、嗜酒、HPV-DNA分型为高危及混合、合并其他性病、疣体直径≥0.5 cm、药物中断是尖锐湿疣患者复发的危险因素。结论Foxp3≥0.195%、IL-10≥394.210 ng/L、单纯手术切除、熬夜、嗜酒、HPV-DNA分型为高危及混合、合并其他性病、疣体直径≥0.5 cm、药物中断是尖锐湿疣患者复发的危险因素。

Objective To analyze the value of forkhead box protein 3(Foxp3),interleukin-10(IL-10)combined with clinical features in predicting the recurrence of male patients with intra-anal condyloma acuminatum.Methods The clinical materials of 160 male patients with intra-anal condyloma acuminatum were retrospectively analyzed.According to the recurrence conditions,they were divided into recurrence group(n=98)and non-recurrence group(n=62),and the clinical features as well as Foxp3 and IL-10 levels were compared between the two groups.The best cut-off values of Foxp3 and IL-10 were analyzed by receiver operating characteristic(ROC)curve,and the risk factors of recurrence of condyloma acuminatum were analyzed by Logistic regression model.Results In the recurrence group,the proportions of patients with simple surgical resection,staying up late,drinking,high and mixed types of human papillomavirus and deoxyribonucleic acid(HPV-DNA),other sexually transmitted diseases,wart diameter≥0.5 cm,drug interruption and the levels of Foxp3 and IL-10 were significantly higher than those in the non-recurrence group(P<0.05).ROC curve analysis showed that the areas under the curve of Foxp3 and IL-10 were 0.881 and 0.910,respectively.Logistic regression analysis showed that Foxp3≥0.195%,IL-10≥394.210 ng/L,simple surgical resection,staying up late,drinking,high and mixed types of HPV-DNA,complicated with other sexually transmitted diseases,wart diameter≥0.5 cm,drug interruption were risk factors for recurrence of condyloma acuminatum.Conclusion Foxp3≥0.195%,IL-10≥394.210 ng/L,simple surgical resection,staying up late,drinking,high and mixed types of HPV-DNA,complicated with other sexually transmitted diseases,wart diameter≥0.5 cm,drug interruption are risk factors for recurrence of patients with condyloma acuminatum.