Graves病动物模型构建的研究进展

Research progress in animal model construction of Graves disease

Graves病(GD)是一种器官特异性自身免疫病。目前,GD治疗存在诸多难点,包括药物治疗疗程长、复发率高、缓解率低等。GD动物模型是研究GD病因、发病机制和防治方法的重要工具。近年来,国内外研究通过更换造模材料,改变给药途径、时间与频次以及调整造模动物品系等多种方式,形成了多种有效的造模方法。本文就GD模型构建的现状和研究进展进行综述。

Graves disease(GD)is an organ-specific autoimmune disease.At present,there are many difficulties in the treatment of GD,including the long course of drug treatment,high recurrence rate and low remission rate.GD animal model is an important tool to study the etiology,pathogenesis and prevention of GD.In recent years,a variety of effective modeling methods have been developed by changing modeling materials,changing administration routes,time and frequency,and adjusting the strain of modeling animals.In this paper,the status quo and research progress of GD model construction were reviewed.