基于血液DNA甲基化在肝癌诊断中的研究进展

Research progress of blood-based DNA methylation in diagnosis of liver cancer

肝癌是世界范围内致死率最高的癌症之一,早期诊断率低,通常在发现肝癌时患者已经处于晚期。早期诊断是降低肝癌患者死亡率的重要手段,但目前尚无诊断肝癌的可靠血液学分子标志物。循环游离DNA甲基化检测是诊断肿瘤的一种潜在的非侵入式方法。本文结合循环游离DNA甲基化在肝癌诊断中的最新研究,主要综述血液中单个DNA甲基化标志物、多个DNA甲基化标志物联合及DNA甲基化标志物联合甲胎蛋白(AFP)在肝癌诊断方面的研究进展。

Liver cancer is one of the most lethal cancer types world-wide with low early diagnosis,and the patient is usually in advanced stage when the disease is diagnosed.Early diagnosis is an important means to reduce the mortality of patients with liver cancer,but there is no reliable hematological molecular marker for the diagnosis of liver cancer.Circulating free DNA(cfDNA)methylation detection is a potential non-invasive method for tumor diagnosis.Combined with the recent studies on circulating free DNA methylation in the diagnosis of liver cancer,this paper mainly reviewed the research progress of single DNA methylation markers in blood,the combination of multiple DNA methylation markers,and the combination of DNA methylation markers with alpha-fetoprotein(AFP)in the diagnosis of liver cancer.