早期食管鳞癌患者预后因素分析

Analysis of prognostic factors in patients with early esophageal squamous cell carcinoma

目的探讨影响早期食管鳞癌患者术后的预后因素。方法回顾性选取2010年11月~2016年10月解放军总医院收治的271例早期食管鳞癌患者,采用单因素和多因素分析的方法分析其临床特征和5年生存率的关系。结果早期食管鳞癌患者的5年生存率为64.8%,年龄和肿瘤分化程度与早期食管鳞癌患者的预后有关(P<0.05)。性别、肿瘤大小、吸烟史、饮酒史和家族史差异无统计学意义(P>0.05)。年龄和肿瘤分化程度是影响早期食管鳞癌患者预后的独立影响因素(HR=1.665、1.797,P<0.05)。结论年龄和分化程度是早期食管鳞癌的独立预后因素。

Objective To explore the factors affecting the prognosis of patients with early postoperative esophageal cancer.Methods Univariate and multivariate analysis methods were used to analyze the relationship between clinical factors and 5-year survival rate of 271 patients with early postoperative esophageal squamous cell carcinoma.Results The 5-year survival rate of early esophageal squamous cell carcinoma patients was 64.8%.Age(p=0.042)and the differentiation(p=0.015)are significantly related to the prognosis of patients with early stage esophageal squamous cell carcinoma.No statistical difference was found in gender,tumor size,smoking,drinking and family history(p>0.05).Age(p=0.017,HR=1.665)and differentiation(p=0.006,HR=1.797)are independent factors affecting the prognosis of patients with early esophageal squamous cell carcinoma.Conclusion Age and differentiation are independent prognostic factors for early esophageal squamous cell carcinoma.