血清人附睾蛋白4在宫颈腺癌诊断中的临床应用

Clinical application of serum human epididymal protein 4 in the diagnosis of cervical adenocarcinoma

目的探讨宫颈腺癌患者血清人附睾蛋白4(HE4)水平变化的临床应用价值。方法采用ELISA法检测受试者血清HE4的水平,采用单因素和多因素Logistic回归分析探讨血清HE4与宫颈腺癌临床病理特征的相关性,绘制ROC曲线,并分析其诊断效能。结果宫颈腺癌组血清HE4水平较良性病变组和正常对照组均明显升高,且差异有统计学意义(P均<0.05)。通过Logistic回归分析,发现血清HE4水平与宫颈腺癌患者的月经状态、组织学分级、淋巴结转移及FIGO分期相关(P均<0.05)。绘制血清HE4诊断宫颈腺癌的ROC曲线,曲线下面积AUC值=0.741,当约登指数最大时,敏感度为59.60%,特异度为87.10%。结论血清HE4水平在宫颈腺癌患者中存在异常升高,对辅助诊断宫颈腺癌、评估宫颈腺癌分期及判断是否有淋巴结转移等具有一定的临床价值。

Objective To explore the clinical value of serum human epididymal protein 4(HE4)level in patients with cervical adenocarcinoma.Methods ELISA was used to detect the level of serum HE4,the univariate and multivariate Logistic regression analysis were used to explore the correlation between serum HE4 and clinical pathological characteristics of cervical adenocarcinoma.The ROC curve was used to analyze diagnostic performance.Results The serum HE4 level of the cervical adenocarcinoma group was significantly higher than that of the benign lesion group and the control group,and the difference was statistically significant(P<0.05).The Logistic regression analysis showed that the serum HE4 level was related to the menstrual status,histological grade,lymph node metastasis and FIGO staging of patients with cervical adenocarcinoma(P<0.05).The ROC curve showed the area under the curve was 0.741,when the Youden index is the largest,the sensitivity is 59.60%and the specificity is 87.10%.Conclusion The level of serum HE4 is abnormally elevated in patients with cervical adenocarcinoma.It has certain clinical value in assisting diagnosis of cervical adenocarcinoma,evaluating cervical adenocarcinoma staging,and judging whether there is lymph node metastasis.