孕产妇静脉血栓栓塞症预防与管理的最佳证据总结

Evidence summary for prevention and management of venous thromboembolism in pregnant women

目的总结孕产妇静脉血栓栓塞症预防与管理的最佳证据。方法检索UpToDate、Cochrane Library、JBI、PubMed、中国知网、万方等数据库以及美国妇产科医师协会、英国国家卫生与临床优化研究所、英国皇家妇产科医师学会等网站中有关孕产妇静脉血栓栓塞症预防与管理的证据,检索时限为建库至2019年12月。2名研究者采用指南研究与评价工具(AGREE Ⅱ)和澳大利亚JBI循证卫生保健中心的标准对文献进行质量评价,并进行证据提取。结果共纳入文献14篇,包括指南7篇、系统评价2篇、专家共识3篇、证据总结1篇、最佳实践信息册1篇,最终获取了25条最佳证据,包括风险评估、预防措施、管理策略、健康教育4个方面。结论本研究总结了孕产妇静脉血栓栓塞症预防与管理的最佳证据,为临床管理者提供循证依据,保证孕产妇安全。

Objective To summary the best evidences for prevention and management of venous thromboembolism in pregnant women.Methods We searched the literatures on the prevention and management of maternal venous thromboembolism in the following databases:UpToDate,Cochrane Library,JBI,PubMed,CNKI,Wanfang Database,American College of Obstetricians and Gynecologists,National Institute for Health and Care Excellence,the Royal College of Obstetricians and Gynaecologists,etc.The search time limit was from database inception to December 2019.Two researchers used AGREEⅡand the standards of the Australian JBI Evidence-based Health Care Center to evaluate the quality of the literature and conduct data extraction.Results A total of fourteen references were included,and they were seven clinical practice guidelines,two systematic reviews,three expert consensuses,one evidence summary,and one best practice information sheet.Twenty-five pieces of best evidence were obtained,including risk assessment,prevention measures,management strategy and health education.Conclusion This study summarizes the best evidences for the prevention and management of venous thromboembolism in pregnant women,and provides evidence for clinical managers to ensure maternal safety.