A6型与A16型手足口病发热持续时间与细胞免疫关系

Relationship between the duration of fever and cellular immunity in patients with A6 and A16 types of hand foot-mouth disease

目的检测A6型与A16型手足口病发热持续时间与细胞免疫的相关性。方法选择A6型、A16型的轻症手足口病患者,其中A6型有183例,将A6型组中CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)均未降低至正常范围的74例列为A6型正常组,将CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)有1个或者多个降低至正常范围的109例列为A6型异常组。A16型有73例,将A16型组中CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)均未降低至正常范围的28例列为A16型正常组,将CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)有1个或者多个降低至正常范围的45例列为A16型异常组。分别比较A6型正常组和A6型异常组、A6型正常组和A16型正常组、A16型正常组和A16型异常组、A6型异常组和A16型异常组的发热持续时间差异。结果A6型正常组和A6型异常组之间发热持续时间比较,差异无统计学意义(t=-1.34,P>0.05),A6型正常组和A16型正常组之间发热持续时间比较,差异无统计学意义(t=2.36,P>0.05)。A16型异常组患者的发热持续时间长于A16型正常组,差异有统计学意义(t=-3.83,P<0.05),A16型异常组患者的发热持续时间长于A6型异常组,差异有统计学意义(t=-4.00,P<0.05)。结论细胞免疫与A16型手足口病发热持续时间有高度相关性,细胞免疫与A6型手足口病发热持续时间无高度相关性。

Objective To detect the correlation between the duration of fever and cellular immunity in patients with A6 and A16 types of hand-foot-mouth disease. Methods The cases with A6,A16 types of mild hand-foot-mouth disease were selected.Of them,183 cases of A6 type,and 73 cases of A16 type.Totally 74 cases in the A6 type group whose CD3+,CD4+,CD8+,CD4+/CD8+ were not reduced to the normal range were classified as the A6 type normal group,and the other109 cases that reduced to the normal range were classified as A6 type abnormal group.Totally 28 cases in the A16 type group whose CD3+,CD4+,CD8+,CD4+/CD8+ were not reduced to the normal range were classified as the A16 type normal group,and the other 45 cases that reduced to the normal range were classified as A16 type abnormal group.The differences in fever duration among these groups were compared respectively. Results There was no statistically significant difference in the duration of fever between the A6 type normal group and the A6 type abnormal group(t=-1.34,P>0.05).The difference in the duration of fever between the A6 type normal group and the A16 type normal group was not statistically significant(t=2.36,P>0.05).The duration of fever of patients in the A16 type abnormal group was longer than that of the A16 type normal group(t=-3.83,P<0.05).The patients in the A16 type abnormal group had a longer fever duration than the A6 type abnormal group(t=-4.00,P<0.05). Conclusion The cellular immunity is highly correlated with the duration of fever in the A16 type of hand-foot-mouth disease,while is not highly correlated with the duration of fever in the A6 type of hand-foot-mouth disease.