宫腔灌注人绒毛膜促性腺激素对反复移植失败患者冻融胚胎移植后妊娠结局的影响

Effect of intrauterine infusion of human chorionic gonadotropin on pregnancy outcome after freeze-thaw embryo transfer in patients with repeated transplant failure

目的:探讨宫腔灌注人绒毛膜促性腺激素(HCG)对反复移植失败患者冻融胚胎移植(FET)后妊娠结局的影响。方法:回顾性分析广西医科大学第三附属医院生殖医疗中心2017年7月至2019年6月反复移植失败行FET的患者共383例,根据FET移植前1日是否行HCG宫腔灌注分为研究组(196例)和对照组(187例),研究组于移植前一日给予宫腔灌注HCG 2 000U,对照组未行宫腔灌注,比较两组的胚胎种植率、临床妊娠率及早期流产率。结果:研究组临床妊娠率为48.5%,显著高于对照组的33.7%(P<0.05),两组早期流产率比较,差异无统计学意义(P>0.05)。结论:在FET周期中,移植前行宫腔灌注HCG,可提高反复移植失败患者的胚胎着床率和临床妊娠率。

Objective: To explore the impact of intrauterine infusion of human chorionic gonadotropin on the pregnancy outcome of frozen embryo transfer in patients with repeated transplantation failures.Methods:A retrospective analysis was conducted on 383 patients who underwent freeze-thaw embryo transfer from July 2017 to June 2019 in our hospital. The patients were divided into a study group(196 cases) and a control group(187 cases). The study group received 2,000 U intrauterine infusion of HCG on the day before transplantation, while the control group did not receive intrauterine infusion. The embryo implantation rate, clinical pregnancy rate and early abortion rate were compared between the two groups. Results: The clinical pregnancy rate in the study group(48.5%) was significantly higher than that in the control group(33.7%)(P<0.05). There was no significant difference in the rate of early abortion between the two groups(P>0.05). Conclusion:In the FET cycle, intrauterine perfusion of HCG before transplantation can increase the embryo implantation rate and clinical pregnancy rate of patients with repeated transplantation failures.