重楼内生真菌研究进展

Research progress of endophytic fungi in Paridis Rhizoma

重楼(Paridis Rhizoma)是一种珍稀濒危中药材。随着我国中医药产业的迅速发展,重楼的市场需求激增,但重楼野生药用资源匮乏,人工繁殖困难,寻找重楼生物活性代替物将成为未来的研究趋势。内生真菌是具有生物活性化合物的重要来源,可以产生种类繁多的次生代谢产物。为了挖掘重楼内生真菌的潜在应用价值,本文对重楼内生真菌的多样性、次生代谢产物种类及药理活性、生物转化等方面的研究进展进行综述,以期为重楼内生真菌的进一步开发利用提供参考。

Paridis Rhizoma is a precious rare and endangered medicinal materials. With the rapid development of traditional Chinese medicine industry,the market demand for Paridis Rhizoma is surging. However, due to the lack of wild medicinal resources of Paridis Rhizoma and the difficulties of artificial reproduction, it will be a research trend to find bioactive substitutes of Paridis Rhizoma in the future. Endophytic fungi are important sources of bioactive compounds, which can produce a variety of secondary metabolites. In order to explore the potential application value of the endophytic fungi of Paridis Rhizoma, this paper reviews the research progress of the endophytic fungi in terms of their diversity, the types of secondary metabolites, pharmacological activity and biotransformation, so as to provide reference for the further development and utilization of the endophytic fungi in Paridis Rhizoma.